| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T06037 | ||||
| Target Name | JNK2 messenger RNA (JNK2 mRNA) | ||||
| Type of Target |
Literature-reported |
||||
| Drug Potency against Target | AS-601245 | Drug Info | IC50 = 5000 nM | [2] | |
| N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)acetamide | Drug Info | Ki = 440 nM | [1] | ||
| N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide | Drug Info | Ki = 1900 nM | [1] | ||
| N-(4-amino-6-butoxy-5-cyanopyridin-2-yl)acetamide | Drug Info | IC50 = 4663 nM | [1] | ||
| References | |||||
| REF 1 | Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80. | ||||
| REF 2 | The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. | ||||
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