| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T10513 | ||||
| Target Name | Integrin beta-2 (ITGB2) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | A-286982 | Drug Info | IC50 = 44 nM | [1] | |
| BMS-587101 | Drug Info | IC50 = 20 nM | [2] | ||
| References | |||||
| REF 1 | Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism o... J Med Chem. 2001 Apr 12;44(8):1202-10. | ||||
| REF 2 | Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thioph... J Med Chem. 2006 Nov 30;49(24):6946-9. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.