| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T11451 | ||||
| Target Name | Toll-like receptor 9 (TLR9) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | CPG 52364 | Drug Info | IC50 = 2 nM | [1] | |
| Action against Disease Model | Agatolimod | Drug Info | Agatolimod selectively targets Toll-like receptor 9 (TLR9), thereby activating dendritic and B cells and stimulating cytotoxic T cell and antibody responses against t uMor cellsbearing t uMor antigens. | ||
| References | |||||
| REF 1 | A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol. 2008 Jan;26(1):127-32. | ||||
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