Target Validation Information
TTD ID	T21434
Target Name	Neuronal acetylcholine receptor alpha-10 (CHRNA10)
Type of Target	Clinical trial
Drug Potency against Target	ACV-1	Drug Info	IC50 = 19 nM
Action against Disease Model	ACV-1	Drug Info	Stable MDA-MB-231 breast cancer cell lines were established in which expression of the alpha9-nAChR subunit was inhibited using short interfering RNA. MCF-10A normal h uMan breast epithelial cells were established in which the alpha9-nAChR subunit could be conditionally overexpressed by removal of doxycycline from the culture fluid. Cell proliferation and soft agar assays and t uMor growth in nude mice were used as measures of cell transformation. All statistical tests were two-sided.	[1]
References
REF 1	Overexpression and activation of the alpha9-nicotinic receptor during tumorigenesis in human breast epithelial cells. J Natl Cancer Inst. 2010 Sep 8;102(17):1322-35.

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