Target Validation Information
TTD ID	T22658
Target Name	Interleukin-8 (IL8)
Type of Target	Successful
Drug Potency against Target	2-(2-(2,5-dichlorophenylamino)phenyl)acetic acid	Drug Info	IC50 = 25 nM	[1]
	2-(2-(2-chlorophenoxy)phenyl)acetic acid	Drug Info	IC50 = 500 nM	[1]
	2-(2-(2-chlorophenylamino)phenyl)acetic acid	Drug Info	IC50 = 400 nM	[1]
	2-(2-(2-fluorophenoxy)phenyl)acetic acid	Drug Info	IC50 = 13 nM	[1]
	2-(2-(2-fluorophenylamino)phenyl)acetic acid	Drug Info	IC50 = 9 nM	[1]
	Ibuprofen	Drug Info	IC50 = 50 nM	[1]
	R-ketoprofen	Drug Info	IC50 = 20 nM	[1]
References
REF 1	Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.