| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T22976 | ||||
| Target Name | Thymidine kinase 2 (Mt-TK2) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | 1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | Drug Info | IC50 = 3300 nM | [1] | |
| 1-[5-(triphenylmethoxy)pentyl]thymine | Drug Info | IC50 = 15000 nM | [1] | ||
| 1-[6-(triphenylmethoxy)hexyl]thymine | Drug Info | IC50 = 17000 nM | [1] | ||
| References | |||||
| REF 1 | N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem. 2006 Dec 28;49(26):7766-73. | ||||
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