Target Validation Information
TTD ID	T26500
Target Name	Histamine H4 receptor (H4R)
Type of Target	Clinical trial
Drug Potency against Target	(1H-indol-2-yl)(piperazin-1-yl)methanone	Drug Info	Ki = 38 nM	[1]
	(R)-3-(1H-imidazol-4-yl)propyl sec-butylcarbamate	Drug Info	Ki = 290 nM	[5]
	2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole	Drug Info	Ki = 1.1 nM
	6-(4-Methylpiperazin-1-yl)-9H-purin-2-amine	Drug Info	Ki = 15600 nM	[4]
	6-(4-methylpiperazin-1-yl)-9Hpurine	Drug Info	Ki = 18400 nM	[4]
	6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine	Drug Info	Ki = 290 nM	[4]
	9-benzyl-6-(4-methylpiperazin-1-yl)-9H-purine	Drug Info	Ki = 14300 nM	[4]
	A-846714	Drug Info	Ki = 35 nM	[3]
	A-943931	Drug Info	Ki = 4.7 nM	[3]
	[125I]iodophenpropit	Drug Info	Ki = 7.8 nM	[2]
References
REF 1	Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists. J Med Chem. 2005 Dec 29;48(26):8289-98.
REF 2	Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening. J Med Chem. 2008 Jun 12;51(11):3145-53.
REF 3	Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and... J Med Chem. 2008 Oct 23;51(20):6547-57.
REF 4	2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. Bioorg Med Chem. 2009 Oct 15;17(20):7186-96.
REF 5	Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6682-5.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.