| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T26617 | ||||
| Target Name | Lactase-phlorizin hydrolase (LCT) | ||||
| Type of Target |
Literature-reported |
||||
| Drug Potency against Target | 2,5-dideoxy-2,5-imino-D-altritol | Drug Info | IC50 = 7200 nM | [2] | |
| 2,5-dideoxy-2,5-imino-dl-glycero-D-manno-heptitol | Drug Info | IC50 = 4000 nM | [3] | ||
| Hyacinthacine B3 | Drug Info | IC50 = 18000 nM | [1] | ||
| References | |||||
| REF 1 | New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica. J Nat Prod. 2002 Dec;65(12):1875-81. | ||||
| REF 2 | 2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease. Bioorg Med Chem. 2010 Jun 1;18(11):3790-4. | ||||
| REF 3 | Nitrogen-containing furanose and pyranose analogues from Hyacinthus orientalis. J Nat Prod. 1998 May;61(5):625-8. | ||||
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