Target Validation Information
TTD ID	T32247
Target Name	Calcitonin receptor (CALCR)
Type of Target	Successful
Drug Potency against Target	CGNLSTCBLGTYTQDFNKFHZYPQTAIGVGAP-amide	Drug Info	IC50 = 79 nM	[1]
	CGNLSTCBLGTYTQDF[DKFHO]YPQTAIGVGAP-amide	Drug Info	IC50 = 5.39 nM	[1]
	CGNLSTCMLGTYTQDFc[DKFHK]FPQTAIGVGAP-amide	Drug Info	IC50 = 60 nM	[1]
	CGNLSTCMLGTYTQDFc[DKFHO]FPQTAIGVGAP-amide	Drug Info	IC50 = 173 nM	[1]
	CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP-amide	Drug Info	IC50 = 2450 nM	[1]
	CGNLSTCMLGTYTQDFNKPHTFPQTAIGVGAP-amide	Drug Info	Ki = 400 nM	[1]
	CGNLSTCMLGTYTQDFNPFHTFPQTAIGVGAP-amide	Drug Info	IC50 = 1905 nM	[1]
	CGNLSTCMLGTYTQDFNPKHTFPQTAIGVGAP-amide	Drug Info	Ki = 2569 nM	[1]
	CSNLSTCVLGKLSQELc[DKLHK]YPRTNTGSGTP-amide	Drug Info	IC50 = 0.18 nM	[1]
	CSNLSTCVLGKLSQELc[DKLHO]YPRTNTGSGTP-amide	Drug Info	IC50 = 0.249 nM	[1]
	CSNLSTCVLGKLSQELc[DKLQK]YPRTNTGSGTP-amide	Drug Info	IC50 = 0.326 nM	[1]
	CSNLSTCVLGKLSQELHKLQTYPRTNTGSGTP-amide	Drug Info	IC50 = 0.377 nM	[1]
	CSNLSTCVLGKLSQELNKLHBYPRTNTGSGTP-amide	Drug Info	IC50 = 0.408 nM	[1]
References
REF 1	Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept fo... J Med Chem. 2002 Feb 28;45(5):1108-21.

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