Target Validation Information
TTD ID T33901
Target Name Niemann-Pick C1-like protein 1 (NPC1L1)
Type of Target
Successful
Drug Potency against Target Ezetimibe-glucuronide Drug Info IC50 = 30 nM [1]
References
REF 1 Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2965-8.

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