| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T35194 | ||||
| Target Name | Dual specificity protein phosphatase 1 (DUSP1) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | 4-ethoxynaphthalene-1,2-dione | Drug Info | IC50 = 820 nM | [1] | |
| ADOCIAQUINONE B | Drug Info | IC50 = 1100 nM | [1] | ||
| Avastin+/-Tarceva | Drug Info | IC50 = 13000 nM | [1] | ||
| References | |||||
| REF 1 | Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. | ||||
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