Target Validation Information
TTD ID	T40954
Target Name	Xanthine dehydrogenase/oxidase (XDH)
Type of Target	Successful
Drug Potency against Target	Allopurinol	Drug Info	IC50 = 776 nM	[3]
	Febuxostat	Drug Info	IC50 = 3 nM	[4]
	1,2,3,4,6-penta-O-galloyl-beta-D-glucose	Drug Info	IC50 = 3200 nM
	1-(3-Cyano-phenyl)-1H-pyrazole-4-carboxylic acid	Drug Info	IC50 = 3300 nM	[1]
	3,4'-(1H-1,2,4-triazole-3,5-diyl)dipyridine	Drug Info	IC50 = 130 nM	[2]
	3,5-bis(2-methylpyridin-4-yl)-1H-1,2,4-triazole	Drug Info	IC50 = 310 nM	[2]
	3,5-di(pyridin-4-yl)-1H-1,2,4-triazole	Drug Info	IC50 = 170 nM	[2]
	ACACETIN	Drug Info	IC50 = 14100 nM
	BAICALEIN	Drug Info	IC50 = 3300 nM
	CHRYSOERIOL	Drug Info	IC50 = 14000 nM
	LIQUIRTIGENIN	Drug Info	IC50 = 11300 nM
	ROBINETIN	Drug Info	IC50 = 4300 nM
	SCUTELLAREIN	Drug Info	IC50 = 12600 nM
References
REF 1	Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors. Bioorg Med Chem Lett. 2001 Apr 9;11(7):879-82.
REF 2	Discovery of 3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 - a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia [... Bioorg Med Chem Lett. 2009 Nov 1;19(21):6225-9.
REF 3	Biochemical characterization of some pyrazolopyrimidine-based inhibitors of xanthine oxidase. Biochemistry (Mosc). 2006;71 Suppl 1:S49-54.
REF 4	Synthesis of some 5-phenylisoxazole-3-carboxylic acid derivatives as potent xanthine oxidase inhibitors. Eur J Med Chem. 2010 Jun;45(6):2663-70.

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