Target Validation Information
TTD ID	T43739
Target Name	Voltage-gated sodium channel alpha Nav1.8 (SCN10A)
Type of Target	Successful
Drug Potency against Target	Tetracaine	Drug Info	IC50 = 700 nM	[4]
	1-[5-(4-Chlorophenyl)-2-furoyl]piperazine	Drug Info	IC50 = 2900 nM	[2]
	5-(4-chlorophenyl)-N-(2-methylbenzyl)nicotinamide	Drug Info	IC50 < 30 nM	[3]
	N-(2-chlorobenzyl)-5-(4-chlorophenyl)nicotinamide	Drug Info	IC50 = 81 nM	[3]
	N-benzyl-5-(4-chlorophenyl)nicotinamide	Drug Info	IC50 = 620 nM	[3]
	SCH-725737	Drug Info	IC50 = 9000 nM	[1]
References
REF 1	Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5543-7.
REF 2	Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain. Bioorg Med Chem. 2008 Jun 15;16(12):6379-86.
REF 3	Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6812-5.
REF 4	Fundamental properties of local anesthetics: half-maximal blocking concentrations for tonic block of Na+ and K+ channels in peripheral nerve. Anesth Analg. 1998 Oct;87(4):885-9.

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