Target Validation Information
TTD ID	T50269
Target Name	Strychnine-binding glycine receptor (GLRA1)
Type of Target	Successful
Drug Potency against Target	10-methoxy-ginkgolide C	Drug Info	IC50 = 5200 nM	[2]
	3,14-DIDEHYDROGINKGOLIDE A	Drug Info	IC50 = 3100 nM	[2]
	3-demethoxy-3-D-lyxopyranosylaminothiocolchicine	Drug Info	IC50 = 4100 nM	[1]
	3-demethoxy-3-D-mannopyranosylaminothiocolchicine	Drug Info	IC50 = 13100 nM	[1]
	3-demethoxy-3-D-xylopyranosylaminothiocolchicine	Drug Info	IC50 = 3300 nM	[1]
	3-demethoxy-3-L-fucopyranosylaminothiocolchicine	Drug Info	IC50 = 4200 nM	[1]
	3-demethoxy-3D-glucopyranosylaminothiocolchicine	Drug Info	IC50 = 10600 nM	[1]
	GINKGOLIDE A	Drug Info	IC50 = 3800 nM	[2]
	Ginkgolide C	Drug Info	IC50 = 5900 nM	[2]
	Ginkgolide J	Drug Info	IC50 = 6400 nM	[2]
	Ginkgolide M	Drug Info	IC50 = 650 nM	[2]
	GINKOLIDE B	Drug Info	IC50 = 1700 nM	[2]
	THIOCOLCHICOSIDE	Drug Info	IC50 = 1500 nM	[1]
	[3H]strychnine	Drug Info	IC50 = 14 nM	[1]
References
REF 1	3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7.
REF 2	Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem. 2007 Apr 5;50(7):1610-7.

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