| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T50444 | ||||
| Target Name | Connective tissue growth factor (CTGF) | ||||
| Type of Target |
Clinical trial |
||||
| Action against Disease Model | Ocaperidone | Drug Info | Administration of a neutralizing CTGF-specific monoclonal antibody, FG-3019, had no effect on monolayer cell proliferation, but blocked AIG in soft agar. Consistent with this observation, anti-CTGF treatment of mice bearing established CTGF-expressing t uMors abrogated CTGF-dependent t uMor growth and inhibited lymph node metastases without any toxicity observed in normal tissue. | [1] | |
| References | |||||
| REF 1 | Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis. Cancer Res. 2006 Jun 1;66(11):5816-27. | ||||
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