Target Validation Information
TTD ID	T50547
Target Name	Plasmodium Plasmepsin 1 (Malaria PLA1)
Type of Target	Literature-reported
Drug Potency against Target	KNI-10006	Drug Info	IC50 = 280 nM	[4]
	L-mannitol derivative	Drug Info	Ki = 478 nM	[2]
	PS-777621	Drug Info	Ki = 727 nM	[3]
	SC-5003	Drug Info	IC50 = 500 nM	[1]
References
REF 1	Protease inhibitors: current status and future prospects. J Med Chem. 2000 Feb 10;43(3):305-41.
REF 2	Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations. J Med Chem. 2005 Sep 22;48(19):6090-106.
REF 3	High antiplasmodial activity of novel plasmepsins I and II inhibitors. J Med Chem. 2006 Dec 14;49(25):7440-9.
REF 4	alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases. Bioorg Med Chem. 2009 Aug 15;17(16):5933-49.

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