Target Validation Information
TTD ID T53378
Target Name Carbonic anhydrase IV (CA-IV)
Type of Target
Successful
Drug Potency against Target 1-(3,4-dichlorophenyl)-3-hydroxyurea Drug Info Ki = 890 nM [9]
2,4-Disulfamyltrifluoromethylaniline Drug Info Ki = 4830 nM [6]
2-oxo-2H-chromene-3-carboxylic acid Drug Info Ki = 9700 nM [16]
2-Propyl-pentanoic acid 4-sulfamoyl-benzyl ester Drug Info Ki = 333 nM [1]
2-Propyl-pentanoic acid 4-sulfamoyl-benzylamide Drug Info Ki = 210 nM [1]
3-Amino-benzenesulfonamide Drug Info Ki = 7750 nM [6]
4-(2-AMINOETHYL)BENZENESULFONAMIDE Drug Info Ki = 3570 nM [6]
4-Amino-3-bromo-benzenesulfonamide Drug Info Ki = 96 nM [6]
4-Amino-3-chloro-benzenesulfonamide Drug Info Ki = 450 nM [6]
4-Amino-3-fluoro-benzenesulfonamide Drug Info Ki = 910 nM [6]
4-Amino-3-iodo-benzenesulfonamide Drug Info Ki = 920 nM [6]
4-Hydrazino-benzenesulfonamide Drug Info Ki = 7700 nM [6]
6-(aminomethyl)-2H-chromen-2-one Drug Info Ki = 15000 nM [16]
6-(hydroxymethyl)-2H-chromen-2-one Drug Info Ki = 7700 nM [16]
6-methyl-2-oxo-2H-chromene-3-carboxylic acid Drug Info Ki = 8500 nM [16]
7-(benzyloxy)-2H-chromen-2-one Drug Info Ki = 5800 nM [16]
Aminocarbonyl dihydrogen phosphate Drug Info Ki = 9900 nM [7]
BENZOLAMIDE Drug Info Ki = 12 nM [2]
Carbamoyl phosphate disodium Drug Info Ki = 9900 nM [3]
CATECHIN Drug Info Ki = 4900 nM [21]
CATECHOL Drug Info Ki = 10900 nM [17]
CL-5343 Drug Info Ki = 940 nM [20]
COUMARIN Drug Info Ki = 6800 nM [16]
Coumate Drug Info Ki = 24 nM [11]
Curcumin Drug Info Ki = 4970 nM [21]
Decane-1,10-diyl disulfamate Drug Info Ki = 91.2 nM [15]
Decyl sulfamate Drug Info Ki = 67.6 nM [15]
ELLAGIC ACID Drug Info Ki = 9080 nM [17]
Ethyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate Drug Info Ki = 7200 nM [16]
FERULIC ACID Drug Info Ki = 10800 nM [17]
GALLICACID Drug Info Ki = 9800 nM [17]
HERNIARIN Drug Info Ki = 8300 nM [16]
Hexane-1,6-diamine Drug Info Ki = 450 nM [19]
Malonate sodium Drug Info Ki = 2800 nM [5]
N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide Drug Info Ki = 8640 nM [12]
N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide Drug Info Ki = 5540 nM [12]
N-(5-Sulfamoyl-[1,3,4]thiadiazol-2-yl)-benzamide Drug Info Ki = 21 nM [1]
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide Drug Info Ki = 8400 nM [12]
N-(phosphonacetyl)-L-aspartate Drug Info Ki = 79 nM [7]
N-1,3,4-thiadiazol-2-ylsulfamide Drug Info Ki = 8910 nM [12]
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide Drug Info Ki = 7580 nM [12]
N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide Drug Info Ki = 8300 nM [12]
N1-(naphthalen-1-yl)ethane-1,2-diamine Drug Info Ki = 58 nM [19]
Octane-1,8-diyl disulfamate Drug Info Ki = 84.1 nM [15]
Octyl sulfamate Drug Info Ki = 79.9 nM [15]
P-Coumaric Acid Drug Info Ki = 9600 nM [17]
PARABEN Drug Info Ki = 7780 nM [17]
Pentane-1,5-diamine Drug Info Ki = 52 nM [19]
PHENOL Drug Info Ki = 9500 nM [21]
Phenyl Boronic acid Drug Info Ki = 880 nM [13]
Phenyl-phosphonic acid Drug Info Ki = 5400 nM [7]
Phenylarsonic acid Drug Info Ki = 870 nM [4]
Salicyclic acid Drug Info Ki = 11100 nM [10]
SODIUM CITRATE Drug Info Ki = 99 nM [5]
Sodium phenylarsonate Drug Info Ki = 870 nM [13]
SODIUM PHOSPHATE, DIBASIC, ANHYDROUS Drug Info Ki = 9800 nM [3]
Sodium pyruvate Drug Info Ki = 14500 nM [5]
Sodium sulfamate Drug Info Ki = 930 nM [13]
Sodium trithiocarbonate Drug Info Ki = 9900 nM [14]
SPERMINE Drug Info Ki = 10 nM [19]
SULFAMATE Drug Info Ki = 930 nM [4]
SULFAMIDE Drug Info Ki = 880 nM [18]
Sulfamylon Drug Info Ki = 8600 nM [6]
Syringic Acid Drug Info Ki = 10600 nM [17]
Trisodium phosphate Drug Info Ki = 84 nM [3]
[Cu(CN)2]- Drug Info Ki = 9800 nM [8]
[Fe(CN)6]4- Drug Info Ki = 10000 nM [8]
References
REF 1 Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties. J Med Chem. 2002 Jan 17;45(2):312-20.
REF 2 Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide. Bioorg Med Chem Lett. 2003 Sep 1;13(17):2867-73.
REF 3 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral dru... Bioorg Med Chem Lett. 2004 Dec 6;14(23):5763-7.
REF 4 Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5769-73.
REF 5 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):573-8.
REF 6 Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54.
REF 7 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1683-6.
REF 8 Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1909-13.
REF 9 N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4316-20.
REF 10 Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
REF 11 Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6.
REF 12 Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5.
REF 13 Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1155-8.
REF 14 Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1855-7.
REF 15 Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8.
REF 16 Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44.
REF 17 Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164.
REF 18 Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5.
REF 19 Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22.
REF 20 Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a l... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4376-81.
REF 21 Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.

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