Target Validation Information
TTD ID	T68698
Target Name	Adenosylhomocysteinase (AHCY)
Type of Target	Literature-reported
Drug Potency against Target		Drug Info	IC50 = 30 nM	[5]
	5'-deoxy-5'-ureidoadenosine	Drug Info	IC50 = 7530 nM	[2]
	5-methylenearisteromycin	Drug Info	IC50 = 15700 nM	[3]
	ARISTEROMYCIN	Drug Info	IC50 = 4850 nM	[3]
	FLUORO-NEPLANOCIN A	Drug Info	IC50 = 480 nM	[1]
	NORARISTEROMYCIN	Drug Info	IC50 = 3100 nM	[4]
References
REF 1	Synthesis of 5'-substituted fluoro-neplanocin A analogues: importance of a hydrogen bonding donor at 5'-position for the inhibitory activity of S-a... Bioorg Med Chem Lett. 2004 Nov 15;14(22):5641-4.
REF 2	Design, synthesis, and molecular modeling studies of 5'-deoxy-5'-ureidoadenosine: 5'-ureido group as multiple hydrogen bonding donor in the active ... Bioorg Med Chem Lett. 2007 Aug 15;17(16):4456-9.
REF 3	Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase. Bioorg Med Chem. 2008 Apr 1;16(7):3809-15.
REF 4	Synthesis of 4'-modified noraristeromycins to clarify the effect of the 4'-hydroxyl groups for inhibitory activity against S-adenosyl-L-homocystein... Bioorg Med Chem Lett. 2008 Apr 15;18(8):2615-8.
REF 5	A new structural class of S-adenosylhomocysteine hydrolase inhibitors. Bioorg Med Chem. 2009 Sep 15;17(18):6707-14.

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