| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T70490 | ||||
| Target Name | Dipeptidyl peptidase I (CTSC) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | (S)-2-amino-N-(1-cyano-2-phenylethyl)acetamide | Drug Info | IC50 = 4787 nM | [1] | |
| GNF-PF-5434 | Drug Info | IC50 = 4000 nM | [2] | ||
| References | |||||
| REF 1 | Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3614-7. | ||||
| REF 2 | Substrate optimization for monitoring cathepsin C activity in live cells. Bioorg Med Chem. 2009 Feb 1;17(3):1064-70. | ||||
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