| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T76904 | ||||
| Target Name | Catechol-O-methyl-transferase (COMT) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Entacapone | Drug Info | Ki = 1.86 nM | [1] | |
| Tolcapone | Drug Info | Ki = 2.50 nM | [1] | ||
| References | |||||
| REF 1 | The role of physicochemical properties of entacapone and tolcapone on their efficacy during local intrastriatal administration. Eur J Pharm Sci. 2005 Apr;24(5):503-11. | ||||
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