Target Validation Information
TTD ID	T77400
Target Name	Phosphodiesterase 2A (PDE2A)
Type of Target	Clinical trial
Drug Potency against Target	(2R,3S)-3-(6-Amino-purin-9-yl)-nonan-2-ol	Drug Info	Ki = 1000 nM	[2]
	2-Morpholin-4-yl-8-phenylethynyl-chromen-4-one	Drug Info	IC50 = 6000 nM	[1]
	BAY-60-7550	Drug Info	IC50 = 4.7 nM	[2]
	Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine	Drug Info	IC50 = 19000 nM	[4]
	Benzyl-(2-pyridin-4-yl-quinazolin-4-yl)-amine	Drug Info	IC50 = 17000 nM	[4]
	isobutylmethylxanthine	Drug Info	IC50 = 12000 nM	[3]
References
REF 1	PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2847-51.
REF 2	The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. J Med Chem. 2005 May 19;48(10):3449-62.
REF 3	A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. J Med Chem. 1985 May;28(5):537-45.
REF 4	Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and th... J Med Chem. 1995 Sep 1;38(18):3547-57.

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