Target Validation Information
TTD ID T80896
Target Name Estrogen receptor beta (ESR2)
Type of Target
Successful
Drug Potency against Target Drug Info IC50 = 2800 nM [12]
1,2-Bis-(4-hydroxy-phenyl)-3H-inden-5-ol Drug Info Ki = 1.3 nM [18]
1,8-Dichloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 9 nM [16]
1-Bromo-6-(4-hydroxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 13 nM [16]
1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL Drug Info IC50 = 2.52 nM [16]
1-Fluoro-6-(4-hydroxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 7 nM [16]
2,3-diphenyl-1H-indole Drug Info IC50 = 171 nM [19]
2-(2-Chloro-4-hydroxy-phenyl)-benzooxazol-5-ol Drug Info IC50 = 59 nM [11]
2-(3-Butoxy-4-hydroxy-phenyl)-benzooxazol-6-ol Drug Info IC50 = 3660 nM [11]
2-(3-Chloro-4-hydroxy-phenyl)-benzooxazol-5-ol Drug Info IC50 = 239 nM [11]
2-(3-Chloro-4-hydroxy-phenyl)-benzooxazol-6-ol Drug Info IC50 = 703 nM [11]
2-(3-Fluoro-4-hydroxy-phenyl)-benzooxazol-5-ol Drug Info IC50 = 66 nM [11]
2-(3-Fluoro-4-hydroxy-phenyl)-benzooxazol-6-ol Drug Info IC50 = 39 nM [11]
2-(3-hydroxyphenyl)-1,2'-spirobi[1H-indene]-5-ol Drug Info IC50 = 29 nM [5]
2-(3-hydroxyphenyl)-1,2'-spirobi[1H-indene]-6-ol Drug Info IC50 = 15 nM [5]
2-(4-Hydroxy-naphthalen-1-yl)-benzooxazol-6-ol Drug Info IC50 = 1530 nM [11]
2-(4-Hydroxy-phenyl)-1-p-tolyl-3H-inden-5-ol Drug Info Ki = 1.3 nM [18]
2-(4-Hydroxy-phenyl)-4-methoxy-quinolin-6-ol Drug Info IC50 = 1190 nM [17]
2-(4-Hydroxy-phenyl)-4-vinyl-quinolin-6-ol Drug Info IC50 = 60 nM [17]
2-(4-Hydroxy-phenyl)-7-isopropyl-benzooxazol-5-ol Drug Info IC50 = 82 nM [11]
2-(4-Hydroxy-phenyl)-7-methoxy-benzofuran-5-ol Drug Info IC50 = 10 nM [10]
2-(4-Hydroxy-phenyl)-7-methoxy-benzooxazol-5-ol Drug Info IC50 = 59 nM [11]
2-(4-Hydroxy-phenyl)-7-methyl-benzofuran-5-ol Drug Info IC50 = 5.6 nM [10]
2-(4-Hydroxy-phenyl)-7-phenyl-benzooxazol-5-ol Drug Info IC50 = 235 nM [11]
2-(4-Hydroxy-phenyl)-7-propenyl-benzooxazol-5-ol Drug Info IC50 = 1.42 nM [11]
2-(4-Hydroxy-phenyl)-7-propyl-benzooxazol-5-ol Drug Info IC50 = 11 nM [11]
2-(4-Hydroxy-phenyl)-7-vinyl-benzooxazol-5-ol Drug Info IC50 = 3.5 nM [11]
2-(4-Hydroxy-phenyl)-benzooxazol-5-ol Drug Info IC50 = 49 nM [11]
2-(4-Hydroxy-phenyl)-benzooxazol-6-ol Drug Info IC50 = 50 nM [11]
2-(4-Hydroxy-phenyl)-quinolin-6-ol Drug Info IC50 = 171 nM [17]
2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL Drug Info IC50 = 6 nM [11]
2-(4-hydroxyphenyl)-1,2'-spirobi[1H-indene]-5-ol Drug Info IC50 = 1.1 nM [5]
2-(5-Hydroxy-naphthalen-1-yl)-benzooxazol-6-ol Drug Info IC50 = 5 nM [11]
2-(6-Hydroxy-naphthalen-1-yl)-benzooxazol-5-ol Drug Info IC50 = 15 nM [11]
2-(6-Hydroxy-naphthalen-1-yl)-benzooxazol-6-ol Drug Info IC50 = 3 nM [11]
2-(6-Hydroxy-naphthalen-2-yl)-benzooxazol-5-ol Drug Info IC50 = 521 nM [11]
2-(6-Hydroxy-naphthalen-2-yl)-benzooxazol-6-ol Drug Info IC50 = 533 nM [11]
2-Naphthalen-1-yl-benzooxazol-6-ol Drug Info IC50 = 1050 nM [11]
2-phenyl-1,2'-spirobi[1H-indene]-5'-ol Drug Info IC50 = 1070 nM [5]
3'-Methoxy-4'Hydroxyclomiphene Drug Info IC50 = 780 nM [30]
3,4,6-Trihydroxy-2-(4-hydroxy-phenyl)-inden-1-one Drug Info IC50 = 1380 nM [14]
3,6-Dihydroxy-2-(4-hydroxy-phenyl)-inden-1-one Drug Info IC50 = 2625 nM [14]
3,8-dihydroxy-4-methyl-6H-benzo[c]chromen-6-one Drug Info IC50 = 46 nM [20]
3,8-dihydroxy-7-methyl-6H-benzo[c]chromen-6-one Drug Info IC50 = 49 nM [20]
3-(2-Hydroxy-phenyl)-benzo[d]isoxazol-6-ol Drug Info IC50 = 254 nM [11]
3-(4-Hydroxy-phenyl)-4H-chromen-7-ol Drug Info IC50 = 680 nM [15]
3-(4-Hydroxy-phenyl)-benzo[d]isoxazol-5-ol Drug Info IC50 = 46 nM [11]
3-(4-Hydroxy-phenyl)-benzo[d]isoxazol-6-ol Drug Info IC50 = 54 nM [11]
3-(5-Hydroxy-benzooxazol-2-yl)-benzene-1,2-diol Drug Info IC50 = 963 nM [11]
3-(6-Hydroxy-benzooxazol-2-yl)-benzene-1,2-diol Drug Info IC50 = 181 nM [11]
3-chloro-4-(4-hydroxyphenyl)salicylaldoxime Drug Info Ki = 12 nM [26]
3-hydroxy-4,10-dimethyl-6H-benzo[c]chromen-6-one Drug Info IC50 = 326 nM [20]
3-hydroxy-4,7-dimethyl-6H-benzo[c]chromen-6-one Drug Info IC50 = 93 nM [20]
3-hydroxy-4-methyl-6H-benzo[c]chromen-6-one Drug Info IC50 = 1450 nM [20]
3-hydroxy-8,10-dimethyl-6H-benzo[c]chromen-6-one Drug Info IC50 = 90 nM [20]
4',5,7-trihydroxy-6,8-dimethylisoflavone Drug Info IC50 = 880 nM [4]
4,10-dimethyl-6H-benzo[c]chromene-3,8-diol Drug Info IC50 = 74 nM [20]
4,6,10-trimethyl-6H-benzo[c]chromene-3,8-diol Drug Info IC50 = 24 nM [20]
4,6,6,7-tetramethyl-6H-benzo[c]chromene-3,8-diol Drug Info IC50 = 45 nM [20]
4,6,7,10-tetramethyl-6H-benzo[c]chromene-3,8-diol Drug Info IC50 = 9 nM [20]
4,6,7-trimethyl-6H-benzo[c]chromene-3,8-diol Drug Info IC50 = 8 nM [20]
4,7-dimethyl-6H-benzo[c]chromene-3,8-diol Drug Info IC50 = 88 nM [20]
4-(2-phenyl-1H-benzo[d]imidazol-1-yl)phenol Drug Info IC50 = 137 nM [19]
4-(2-phenyl-1H-indol-3-yl)phenol Drug Info IC50 = 1.12 nM [19]
4-(3-(4-hydroxyphenyl)-1H-indol-2-yl)phenol Drug Info IC50 = 11.9 nM [19]
4-(3-phenyl-1H-indol-2-yl)phenol Drug Info IC50 = 355 nM [19]
4-(5-Hydroxy-benzooxazol-2-yl)-benzene-1,3-diol Drug Info IC50 = 25 nM [11]
4-(6-Hydroxy-benzooxazol-2-yl)-benzene-1,2-diol Drug Info IC50 = 105 nM [11]
4-(6-Hydroxy-benzooxazol-2-yl)-benzene-1,3-diol Drug Info IC50 = 3 nM [11]
4-Benzo[d]isoxazol-3-yl-benzene-1,3-diol Drug Info IC50 = 718 nM [11]
4-Bromo-2-(4-hydroxy-phenyl)-quinolin-6-ol Drug Info IC50 = 4.3 nM [17]
4-Chloro-2-(4-hydroxy-phenyl)-quinolin-6-ol Drug Info IC50 = 4.6 nM [17]
4-Ethyl-2-(4-hydroxy-phenyl)-quinolin-6-ol Drug Info IC50 = 52 nM [17]
4-Ethynyl-2-(4-hydroxy-phenyl)-quinolin-6-ol Drug Info IC50 = 75 nM [17]
4-Naphthalen-2-yl-phenol Drug Info IC50 = 245 nM [16]
4-[1,2-bis(4-hydroxyphenyl)but-1-enyl]phenol Drug Info IC50 = 10 nM [6]
4-[1,2-bis(4-hydroxyphenyl)hex-1-enyl]phenol Drug Info IC50 = 240 nM [6]
4-[1,2-bis(4-hydroxyphenyl)pent-1-enyl]phenol Drug Info IC50 = 70 nM [6]
4-[1,2-bis(4-hydroxyphenyl)vinyl]phenol Drug Info IC50 = 200 nM [6]
4-[2,2-bis(4-hydroxyphenyl)-1-methylvinyl]phenol Drug Info IC50 = 15 nM [6]
5,7-dihydroxy-3-phenyl-3H-quinazolin-4-one Drug Info IC50 = 18472 nM [21]
5-Bromo-2-(4-hydroxy-phenyl)-quinolin-6-ol Drug Info IC50 = 88 nM [17]
5-Chloro-2-(4-hydroxy-phenyl)-benzooxazol-6-ol Drug Info IC50 = 157 nM [11]
5-Chloro-2-(4-hydroxy-phenyl)-quinolin-6-ol Drug Info IC50 = 30 nM [17]
6-(2,5-Difluoro-4-hydroxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 2.8 nM [16]
6-(2,6-Difluoro-4-hydroxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 2.3 nM [16]
6-(2-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 1.4 nM [16]
6-(2-Fluoro-4-hydroxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 2 nM [16]
6-(2-Hydroxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 2000 nM [16]
6-(3,5-Difluoro-4-hydroxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 8.4 nM [16]
6-(3-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 11 nM [16]
6-(3-Fluoro-4-hydroxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 5 nM [16]
6-(3-Hydroxy-phenyl)-naphthalen-1-ol Drug Info IC50 = 205 nM [16]
6-(3-Hydroxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 30 nM [16]
6-(4-Hydroxy-2-methoxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 27 nM [16]
6-(4-Hydroxy-2-methyl-phenyl)-naphthalen-2-ol Drug Info IC50 = 10 nM [16]
6-(4-Hydroxy-phenyl)-1-methoxy-naphthalen-2-ol Drug Info IC50 = 114 nM [16]
6-(4-Hydroxy-phenyl)-1-methyl-naphthalen-2-ol Drug Info IC50 = 17 nM [16]
6-(4-Hydroxy-phenyl)-1-nitro-naphthalen-2-ol Drug Info IC50 = 199 nM [16]
6-(4-Hydroxy-phenyl)-1-phenyl-naphthalen-2-ol Drug Info IC50 = 748 nM [16]
6-(4-Hydroxy-phenyl)-naphthalen-1-ol Drug Info IC50 = 5.8 nM [16]
6-(4-Hydroxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 16 nM [17]
6-Chloro-2-(4-hydroxy-phenyl)-benzooxazol-5-ol Drug Info IC50 = 16 nM [11]
6-ethyl-4,7-dimethyl-6H-benzo[c]chromene-3,8-diol Drug Info IC50 = 3.2 nM [20]
6-Phenyl-naphthalen-2-ol Drug Info IC50 = 374 nM [16]
7-(3-Hydroxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 566 nM [16]
7-(4-Hydroxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 44 nM [16]
7-Allyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol Drug Info IC50 = 13 nM [11]
7-Bromo-2-(4-hydroxy-phenyl)-benzofuran-5-ol Drug Info IC50 = 2 nM [10]
7-Butyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol Drug Info IC50 = 79 nM [11]
7-Chloro-2-(4-hydroxy-phenyl)-benzofuran-5-ol Drug Info IC50 = 1.6 nM [10]
7-Ethyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol Drug Info IC50 = 13 nM [11]
7-Ethynyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol Drug Info IC50 = 15 nM [11]
7-hydroxy-1,2,9,9a-tetrahydrofluoren-3-one Drug Info IC50 = 1530 nM [22]
7-hydroxy-3-(4-hydroxyphenyl)-3H-quinazolin-4-one Drug Info IC50 = 8609 nM [21]
7-Phenyl-naphthalen-2-ol Drug Info IC50 = 527 nM [16]
8-(2,2-dimethylpropyl)naringenin Drug Info IC50 = 141 nM [23]
8-(2-methylpropyl)naringenin Drug Info IC50 = 37 nM [23]
8-(3-methylbutyl)naringenin Drug Info IC50 = 59 nM [23]
8-benzylnaringenin Drug Info IC50 = 244 nM [23]
8-Chloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 2.3 nM [16]
8-Fluoro-6-(4-hydroxy-phenyl)-naphthalen-2-ol Drug Info IC50 = 1.6 nM [16]
8-methylnaringenin Drug Info IC50 = 863 nM [23]
8-n-heptylnaringenin Drug Info IC50 = 69 nM [23]
8-n-nonylnaringenin Drug Info IC50 = 113 nM [23]
8-n-pentylnaringenin Drug Info IC50 = 97 nM [23]
8-n-propylnaringenin Drug Info IC50 = 29 nM [23]
8-n-undecylnaringenin Drug Info IC50 = 421 nM [23]
Afimoxifene Drug Info IC50 = 20 nM [27]
ARZOXIFENE Drug Info IC50 = 66.3 nM [24]
BITHIONOL Drug Info IC50 = 8147.15 nM [29]
BROUSSONIN A Drug Info IC50 = 1800 nM [28]
COUMESTROL Drug Info IC50 = 18.6 nM [15]
daidzein Drug Info IC50 = 1200 nM [4]
DIHYDRORALOXIFENE Drug Info IC50 = 0.52 nM [1]
Doxorubicin-Formaldehyde Conjugate Drug Info IC50 = 300 nM [8]
EFFUSOL Drug Info IC50 = 12 nM [20]
ERA-923 Drug Info IC50 = 40 nM [3]
Geldanamycin-estradiol hybrid Drug Info IC50 = 80 nM [2]
GNF-PF-3037 Drug Info IC50 = 2611.21 nM [29]
HE2100 Drug Info IC50 = 9.9 nM [25]
HEXESTROL Drug Info IC50 = 2 nM
MORIN Drug Info IC50 = 2927.18 nM [29]
Nafoxidine Drug Info IC50 = 40.9 nM [32]
NARINGENIN Drug Info IC50 = 13473 nM [23]
ONAPRISTONE Drug Info Ki < 20 nM [31]
SOPHORAFLAVANONE B Drug Info IC50 = 68 nM [23]
THIOGENISTEIN Drug Info IC50 = 1340 nM [21]
TUPICHINOL C Drug Info IC50 = 14700 nM [28]
WAY-169916 Drug Info IC50 = 106 nM [13]
WAY200070 Drug Info IC50 = 2 nM [11]
ZK-164015 Drug Info IC50 = 1.4 nM [9]
[1,1':2',1'']Terphenyl-4'-carbaldehyde oxime Drug Info Ki = 0.27 nM [7]
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