| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T82702 | ||||
| Target Name | Pregnane X receptor (NR1I2) | ||||
| Type of Target |
Literature-reported |
||||
| Drug Potency against Target | Drug Info | IC50 = 1770 nM | [1] | ||
| WAY-214950 | Drug Info | IC50 = 2160 nM | [1] | ||
| References | |||||
| REF 1 | Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic tr... J Med Chem. 2008 Nov 27;51(22):7161-8. | ||||
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