| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T90553 | ||||
| Target Name | Microtubule affinity regulating kinase 3 (MARK3) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | UCN-01 | Drug Info | IC50 = 27 nM | [2] | |
| Action against Disease Model | UCN-01 | Drug Info | Abrogated DNA damage-induced G2 arrest, leading to mitotic entry and subsequent cell death. | [1] | |
| References | |||||
| REF 1 | Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. | ||||
| REF 2 | The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Res. 2000 Apr 15;60(8):2108-12. | ||||
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