Target Validation Information
TTD ID	T97613
Target Name	Melatonin receptor type 1A (MTNR1A)
Type of Target	Successful
Drug Potency against Target	Ramelteon	Drug Info	Ki = 14 nM	[7]
	4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one	Drug Info	Ki < 1000 nM	[5]
	5-methoxycarbonylamino-N-acetyltryptamine	Drug Info	IC50 = 100 nM	[2]
	Beta,beta-dimethylmelatonin	Drug Info	Ki = 1.12 nM	[1]
	Beta-methylmelatonin	Drug Info	Ki = 1.67 nM	[1]
	N-(2,3,4,9-Tetrahydro-1H-carbazol-3-yl)-acetamide	Drug Info	Ki = 5350 nM
	N-(2,3-Dihydro-1H-phenalen-2-yl)-acetamide	Drug Info	Ki = 195 nM	[6]
	N-(2-(5-methoxybenzofuran-3-yl)ethyl)acetamide	Drug Info	IC50 = 0.6 nM	[2]
	N-(3-(2,5-dimethoxyphenyl)propyl)acetamide	Drug Info	Ki = 1280 nM	[4]
	N-(3-(2-ethoxy-5-methoxyphenyl)propyl)acetamide	Drug Info	Ki = 183 nM	[4]
	N-(3-(2-hydroxy-5-methoxyphenyl)propyl)acetamide	Drug Info	Ki = 379 nM	[4]
	N-(3-(3-methoxyphenyl)-3-phenylallyl)acetamide	Drug Info	Ki = 230 nM	[3]
	N-(3-(3-methoxyphenyl)propyl)acetamide	Drug Info	Ki = 23.3 nM	[4]
	N-(3-(3-methoxyphenyl)propyl)propionamide	Drug Info	Ki = 85.4 nM	[4]
	N-(3-(4-hydroxy-3-methoxyphenyl)propyl)acetamide	Drug Info	Ki = 257 nM	[4]
	N-(3-(5-methoxy-2-propoxyphenyl)propyl)acetamide	Drug Info	Ki = 400 nM	[4]
	N-acetylserotonin	Drug Info	Ki = 1640 nM	[6]
	UCM-454	Drug Info	Ki = 1.4 nM	[3]
References
REF 1	Mapping the melatonin receptor. 7. Subtype selective ligands based on beta-substituted N-acyl-5-methoxytryptamines and beta-substituted N-acyl-5-me... J Med Chem. 2006 Jun 15;49(12):3509-19.
REF 2	Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3. Bioorg Med Chem. 2008 May 1;16(9):4954-62.
REF 3	2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists. J Med Chem. 2009 Feb 12;52(3):826-33.
REF 4	Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2582-5.
REF 5	Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97.
REF 6	Synthesis of 2-amido-2,3-dihydro-1H-phenalene derivatives as new conformationally restricted ligands for melatonin receptors. J Med Chem. 1996 Aug 2;39(16):3089-95.
REF 7	Therapeutic opportunities from muscarinic receptor research. Trends Pharmacol Sci. 2001 Aug;22(8):409-14.

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