Target Validation Information
TTD ID	T98459
Target Name	G2/mitotic-specific cyclin B1 (CCNB1)
Type of Target	Patented-recorded
Drug Potency against Target	3,4-bis(indol-3-yl)maleimide derivative	Drug Info	IC50 = 4500 nM	[3]
	AZAKENPAULLONE	Drug Info	IC50 = 2000 nM	[1]
	Bisindolylmaleimide-I	Drug Info	IC50 = 19000 nM	[3]
	KENPAULLONE	Drug Info	IC50 = 400 nM	[2]
	RO-316233	Drug Info	IC50 = 18000 nM	[3]
	Thieno analogue of kenpaullone	Drug Info	IC50 = 600 nM	[1]
References
REF 1	1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.
REF 2	Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay. Eur J Med Chem. 2010 Sep;45(9):4316-30.
REF 3	Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure. Bioorg Med Chem Lett. 1998 May 5;8(9):1019-22.

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