Target General Infomation
Target ID
T11754 (Former ID: TTDS00177)
Target Name
Fatty acid amide hydrolase (FAAH)
Synonyms
Oleamidehydrolase; Anandamide amidohydrolase
Gene Name
NO-GeName
Target Type
Successful target
[1]
Disease [+] 1 Target-related Diseases +
1 Corneal disease [ICD-11: 9A76-9A78]
Function
Degradesbioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.
UniProt ID
NOUNIPROTAC
Drugs and Modes of Action
Approved Drug(s) [+] 2 Approved Drugs +
1 Propofol Drug Info Approved Anaesthesia [2], [3]
2 Thiopental Drug Info Approved Anaesthesia [4], [5]
Clinical Trial Drug(s) [+] 5 Clinical Trial Drugs +
1 IW-6118 Drug Info Phase 2 Inflammation [6]
2 JNJ-42165279 Drug Info Phase 2 Anxiety disorder [7]
3 PF-04457845 Drug Info Phase 2 Liver disease [8]
4 SSR411298 Drug Info Phase 2 Major depressive disorder [9]
5 IPI-940 Drug Info Phase 1 Pain [10]
Mode of Action [+] 2 Modes of Action +
Inhibitor [+] 299 Inhibitor drugs +
1 Propofol Drug Info [1], [11]
2 Thiopental Drug Info [1]
3 JNJ-42165279 Drug Info [13]
4 PF-04457845 Drug Info [14]
5 SSR411298 Drug Info [15]
6 IPI-940 Drug Info [16]
7 Aryl urea derivative 1 Drug Info [17]
8 Aryl urea derivative 2 Drug Info [17]
9 Aryl urea derivative 3 Drug Info [17]
10 Aryl urea derivative 4 Drug Info [17]
11 Aryl urea derivative 5 Drug Info [17]
12 Azetidine urea derivative 1 Drug Info [17]
13 Azetidine urea derivative 2 Drug Info [17]
14 Azetidine urea derivative 3 Drug Info [17]
15 Azole derivative 1 Drug Info [17]
16 Azole derivative 2 Drug Info [17]
17 Azole derivative 3 Drug Info [17]
18 Azole derivative 4 Drug Info [17]
19 Azole derivative 5 Drug Info [17]
20 Benzoxazole derivative 1 Drug Info [17]
21 Benzyl pyrrolyloxoacetamide derivative 1 Drug Info [17]
22 Benzyl pyrrolyloxoacetamide derivative 2 Drug Info [17]
23 Boronic acid derivative 1 Drug Info [17]
24 Boronic acid derivative 2 Drug Info [17]
25 Boronic acid derivative 3 Drug Info [17]
26 Boronic acid derivative 4 Drug Info [17]
27 Boronic acid derivative 5 Drug Info [17]
28 Boronic acid derivative 6 Drug Info [17]
29 Carbamate derivative 1 Drug Info [17]
30 Carbamate derivative 10 Drug Info [18]
31 Carbamate derivative 16 Drug Info [18]
32 Carbamate derivative 17 Drug Info [18]
33 Carbamate derivative 3 Drug Info [17]
34 Carbamate derivative 7 Drug Info [17]
35 Carbamate derivative 8 Drug Info [17]
36 Carbamate derivative 9 Drug Info [18]
37 Carbamide derivative 1 Drug Info [17]
38 Carbamide derivative 24 Drug Info [18]
39 Carbamide derivative 25 Drug Info [18]
40 Carbamide derivative 26 Drug Info [18]
41 Enol carbamate derivative 1 Drug Info [17]
42 Ethylaminopyrimidine derivative 1 Drug Info [17]
43 Heteroaryl-substituted urea derivative 1 Drug Info [17]
44 Heteroaryl-substituted urea derivative 2 Drug Info [17]
45 Imidazolyl urea derivative 1 Drug Info [17]
46 Isoxazoline derivative 1 Drug Info [17]
47 Isoxazoline derivative 2 Drug Info [17]
48 Isoxazoline derivative 3 Drug Info [17]
49 Isoxazoline derivative 4 Drug Info [17]
50 Ketoheterocycle derivative 1 Drug Info [17]
51 Ketoheterocycle derivative 2 Drug Info [17]
52 Ketoheterocycle derivative 3 Drug Info [17]
53 Ketoheterocycle derivative 4 Drug Info [17]
54 N-alkyl-4-oxazolecar boxamide derivative 1 Drug Info [17]
55 N-alkyl-4-oxazolecar boxamide derivative 2 Drug Info [17]
56 Piperazine carbamic compound 1 Drug Info [18]
57 Piperazine carbamic compound 2 Drug Info [18]
58 Piperazine urea derivative 1 Drug Info [17]
59 PMID26413912-Compound-84 Drug Info [17]
60 PMID29053063-Compound-11d Drug Info [18]
61 PMID29053063-Compound-14 Drug Info [18]
62 PMID29053063-Compound-15 Drug Info [18]
63 Pyrazole derivative 80 Drug Info [18]
64 Pyrazole derivative 81 Drug Info [18]
65 Pyrazole derivative 82 Drug Info [18]
66 Pyrazole derivative 83 Drug Info [18]
67 Pyrazole derivative 84 Drug Info [18]
68 Pyrimidinyl ethylenediamine derivative 1 Drug Info [17]
69 Pyrrolidinyl urea derivative 1 Drug Info [17]
70 Spirocyclic diamine urea derivative 1 Drug Info [17]
71 Spirocyclic diamine urea derivative 2 Drug Info [17]
72 Tetra-hydro-naphthalene derivative 1 Drug Info [17]
73 Tetra-hydro-naphthalene derivative 2 Drug Info [17]
74 Tetra-hydro-naphthalene derivative 3 Drug Info [17]
75 Tetra-hydro-naphthyridine derivative 1 Drug Info [17]
76 Tetra-substituted urea derivative 1 Drug Info [17]
77 Tetra-substituted urea derivative 2 Drug Info [17]
78 Tetrazolyl urea derivative 1 Drug Info [17]
79 (+/-)-3-(but-3-enyl)-1-pent-4-enoylazetidin-2-one Drug Info [19]
80 (+/-)-3-(pent-4-enyl)azetidin-2-one Drug Info [19]
81 (+/-)-3-allyl-1-pent-4-enoylazetidin-2-one Drug Info [19]
82 (+/-)-3-allylazetidin-2-one Drug Info [19]
83 (+/-)-oxiran-2-ylmethyl (9Z)-hexadec-9-enoate Drug Info [20]
84 (+/-)-oxiran-2-ylmethyl (9Z)-octadec-9-enoate Drug Info [20]
85 (Z)-1,1,1-Trifluoro-nonadec-10-en-2-one Drug Info [21]
86 (Z)-1-(4-phenyloxazol-2-yl)octadec-9-en-1-one Drug Info [22]
87 (Z)-1-(benzo[d]oxazol-2-yl)octadec-9-en-1-one Drug Info [22]
88 (Z)-1-(pyridazin-3-yl)octadec-9-en-1-one Drug Info [22]
89 (Z)-2,2-Dimethyl-1-oxazol-2-yl-octadec-9-en-1-one Drug Info [23]
90 (Z)-2-Methyl-1-oxazol-2-yl-octadec-9-en-1-one Drug Info [23]
91 1,1,1-trifluoro-3-(hexylthio)propan-2-one Drug Info [24]
92 1,1,1-trifluoro-3-(octylsulfinyl)propan-2-one Drug Info [24]
93 1,1,1-trifluoro-3-(octylsulfonyl)propan-2-one Drug Info [24]
94 1,1,1-trifluoro-3-(octylthio)propan-2-one Drug Info [24]
95 1,1,1-Trifluoro-7-phenylheptan-2-one Drug Info [21]
96 1,1,1-Trifluoro-8-phenyl-octan-2-one Drug Info [21]
97 1,1,1-Trifluoro-9-phenyl-nonan-2-one Drug Info [21]
98 1,1,1-Trifluoro-nonadecan-2-one Drug Info [21]
99 1,1,1-Trifluoro-tridecan-2-one Drug Info [21]
100 1,1,1-Trifluoro-undecan-2-one Drug Info [21]
101 1,1,1-trifluorododecan-2-one Drug Info [24]
102 1,10-(methylenedi-4,1-phenylene)bismaleimide Drug Info [25]
103 1,4-bis(malimido)xylene Drug Info [25]
104 1,8-bis-maleimidodiethyleneglycol Drug Info [25]
105 1-(1,2,4-Oxadiazol-3-yl)-7-phenylheptan-1-one Drug Info [26]
106 1-(1,2,4-Oxadiazol-5-yl)-7-phenylheptan-1-one Drug Info [26]
107 1-(1,3,4-Oxadiazol-2-yl)-7-phenylheptan-1-one Drug Info [26]
108 1-(1,3,4-oxadiazol-2-yl)octadec-9-en-1-one Drug Info [26]
109 1-(1,3,4-thiadiazol-2-yl)octadec-9-en-1-one Drug Info [26]
110 1-(4-acetyloxazol-2-yl)-7-phenylheptan-1-one Drug Info [27]
111 1-(4-bromooxazol-2-yl)-7-phenylheptan-1-one Drug Info [27]
112 1-(4-chlorooxazol-2-yl)-7-phenylheptan-1-one Drug Info [27]
113 1-(4-iodooxazol-2-yl)-7-phenylheptan-1-one Drug Info [27]
114 1-(4-methoxyoxazol-2-yl)-7-phenylheptan-1-one Drug Info [27]
115 1-(4-methyloxazol-2-yl)-7-phenylheptan-1-one Drug Info [27]
116 1-(5-(furan-2-yl)oxazol-2-yl)octadec-9-en-1-one Drug Info [26]
117 1-(5-(pyridin-2-yl)oxazol-2-yl)dodecan-1-one Drug Info [22]
118 1-(5-(pyridin-2-yl)oxazol-2-yl)octadec-9-en-1-one Drug Info [26]
119 1-(5-(pyridin-2-yl)oxazol-2-yl)octan-1-one Drug Info [22]
120 1-(5-(pyridin-2-yl)oxazol-2-yl)pentan-1-one Drug Info [22]
121 1-(5-fluorooxazol-2-yl)-7-phenylheptan-1-one Drug Info [22]
122 1-(5-methyloxazol-2-yl)-7-phenylheptan-1-one Drug Info [22]
123 1-(5-phenyloxazol-2-yl)octadec-9-en-1-one Drug Info [26]
124 1-(5-Pyridin-2-yl-oxazol-2-yl)-octadec-9-yn-1-one Drug Info [21]
125 1-(oxazol-2-yl)-3-(4-phenoxyphenyl)propan-1-one Drug Info [28]
126 1-(oxazol-2-yl)-4-(piperidin-4-yl)butan-1-one Drug Info [29]
127 1-(oxazol-2-yl)-7-phenylheptan-1-one Drug Info [27]
128 1-(oxazol-2-yl)octadec-9-en-1-one Drug Info [26]
129 1-(oxazolo[4,5-b]pyridin-2-yl)dodecan-1-one Drug Info [22]
130 1-(oxazolo[4,5-b]pyridin-2-yl)octan-1-one Drug Info [22]
131 1-(oxazolo[4,5-b]pyridin-2-yl)pentan-1-one Drug Info [22]
132 1-Benzooxazol-2-yl-6-phenyl-hexan-1-one Drug Info [21]
133 1-Biphenyl-4-ylmaleimide Drug Info [25]
134 1-Biphenyl-4-ylmethylmaleimide Drug Info [25]
135 1-DODECANOL Drug Info [30]
136 1-Imidazol-1-yl-3-(4-octylphenoxy)propan-2-one Drug Info [31]
137 1-Oxazolo[4,5-b]pyridin-2-yl-6-phenyl-hexan-1-one Drug Info [32]
138 1-Oxazolo[4,5-b]pyridin-2-yl-octadec-9-yn-1-one Drug Info [21]
139 2,2-dimethyl-3-methyleneheptadecane Drug Info [24]
140 2,4-difluorophenyl 4-butoxybenzylcarbamate Drug Info [33]
141 2-(7-phenylheptanoyl)oxazole-4-carbaldehyde Drug Info [27]
142 2-(7-phenylheptanoyl)oxazole-4-carbonitrile Drug Info [27]
143 2-(7-phenylheptanoyl)oxazole-4-carboxamide Drug Info [27]
144 2-(7-phenylheptanoyl)oxazole-4-carboxylic acid Drug Info [27]
145 2-(7-phenylheptanoyl)oxazole-5-carbonitrile Drug Info [27]
146 2-(7-phenylheptanoyl)oxazole-5-carboxylic acid Drug Info [27]
147 2-(biphenyl-4-yl)vinylboronic acid Drug Info [34]
148 2-arachidonoylglycerol Drug Info [35]
149 2-chloro-1-(5-(pyridin-2-yl)oxazol-2-yl)ethanone Drug Info [36]
150 2-Cyclohexylacetic acidbiphenyl-3-yl ester Drug Info [37]
151 2-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate Drug Info [33]
152 2-fluorophenyl 4'-ethylbiphenyl-4-ylcarbamate Drug Info [33]
153 2-fluorophenyl 4-(decyloxy)phenylcarbamate Drug Info [33]
154 2-fluorophenyl 4-(dodecyloxy)phenylcarbamate Drug Info [33]
155 2-fluorophenyl 4-(heptyloxy)phenylcarbamate Drug Info [33]
156 2-fluorophenyl 4-(hexyloxy)phenylcarbamate Drug Info [33]
157 2-fluorophenyl 4-(octyloxy)phenylcarbamate Drug Info [33]
158 2-fluorophenyl 4-(undecyloxy)phenylcarbamate Drug Info [33]
159 2-fluorophenyl 4-butoxybenzylcarbamate Drug Info [33]
160 2-fluorophenyl 4-butoxyphenylcarbamate Drug Info [33]
161 2-fluorophenyl 4-phenoxyphenylcarbamate Drug Info [33]
162 2-fluorophenylboronic acid Drug Info [34]
163 2-methoxyphenylboronic acid Drug Info [34]
164 3'-carbamoylbiphenyl-3-yl 6-phenylhexylcarbamate Drug Info [38]
165 3,3-di(pent-4-enyl)azetidin-2-one Drug Info [19]
166 3-(4,5-Dihydrooxazol-2-yl)phenyl propylcarbamate Drug Info [39]
167 3-(benzo[d]oxazol-2-yl)phenyl propylcarbamate Drug Info [39]
168 3-(biphenyl-4-yl)-1-(oxazol-2-yl)propan-1-one Drug Info [28]
169 3-(decylsulfinyl)-1,1,1-trifluoropropan-2-one Drug Info [24]
170 3-(decylsulfonyl)-1,1,1-trifluoropropan-2-one Drug Info [24]
171 3-(decylthio)-1,1,1-trifluoropropan-2-one Drug Info [24]
172 3-(dodecylsulfinyl)-1,1,1-trifluoropropan-2-one Drug Info [24]
173 3-(dodecylsulfonyl)-1,1,1-trifluoropropan-2-one Drug Info [24]
174 3-(ethoxycarbonyl)phenylboronic acid Drug Info [34]
175 3-(trifluoromethyl)phenyl 4-butoxybenzylcarbamate Drug Info [33]
176 3-(trifluoromethyl)phenylboronic acid Drug Info [34]
177 3-chlorophenyl 4-butoxybenzylcarbamate Drug Info [33]
178 3-cyanophenylboronic acid Drug Info [34]
179 3-methoxyphenylboronic acid Drug Info [34]
180 4-(1,2,3-thiadiazol-4-yl)phenyl butylcarbamate Drug Info [40]
181 4-(1,2,3-thiadiazol-4-yl)phenyl hexylcarbamate Drug Info [40]
182 4-(4,5-dihydrothiazol-2-yl)phenyl butylcarbamate Drug Info [40]
183 4-(cyclohexylmethylcarbamoyloxy)benzoic acid Drug Info [38]
184 4-(thiazol-2-yl)phenyl butylcarbamate Drug Info [41]
185 4-(trifluoromethyl)phenylboronic acid Drug Info [34]
186 4-cyanophenyl ethyl dodecylphosphonate Drug Info [42]
187 4-cyanophenylboronic acid Drug Info [34]
188 4-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate Drug Info [33]
189 4-fluorophenyl 4-butoxybenzylcarbamate Drug Info [33]
190 4-fluorophenylboronic acid Drug Info [34]
191 4-methoxyphenyl 1-(4-butoxyphenyl)propylcarbamate Drug Info [33]
192 4-methoxyphenylboronic acid Drug Info [34]
193 4-Nitrophenyl 4-Benzylpiperazine-1-carboxylate Drug Info [43]
194 4-nitrophenylboronic acid Drug Info [34]
195 4-nonylphenylboronic acid Drug Info [34]
196 4-Phenylbutylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
197 6-fluoropyridin-3-ylboronic acid Drug Info [34]
198 6-Phenylhexylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
199 7-Phenyl-1-(1,3,4-thiadiazol-2-yl)-heptan-1-one Drug Info [26]
200 7-Phenyl-1-(2H-tetrazol-5-yl)-heptan-1-one Drug Info [26]
201 7-phenyl-1-(4-phenyloxazol-2-yl)heptan-1-one Drug Info [27]
202 7-phenyl-1-(5-phenyloxazol-2-yl)heptan-1-one Drug Info [26]
203 7-Phenyl-1-(pyridazin-3-yl)-heptan-1-one Drug Info [26]
204 7-Phenyl-1-(thiazol-2-yl)-heptan-1-one Drug Info [26]
205 8-Phenyloctylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
206 Adamant-1-ylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
207 Allylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
208 AM-404 Drug Info [44]
209 AR-C70484XX Drug Info [31]
210 ARACHIDONYL TRIFLUOROMETHYLKETONE Drug Info [31]
211 Benzaldehyde O-4-(decyloxy)phenylcarbamoyl oxime Drug Info [33]
212 Benzaldehyde O-4-(heptyloxy)phenylcarbamoyl oxime Drug Info [33]
213 Benzaldehyde O-4-(hexyloxy)phenylcarbamoyl oxime Drug Info [33]
214 Benzaldehyde O-4-(nonyloxy)phenylcarbamoyl oxime Drug Info [33]
215 Benzaldehyde O-4-(octyloxy)phenylcarbamoyl oxime Drug Info [33]
216 Benzaldehyde O-4-(pentyloxy)phenylcarbamoyl oxime Drug Info [33]
217 Benzaldehyde O-4-butoxyphenylcarbamoyl oxime Drug Info [33]
218 Benzaldehyde O-4-ethoxyphenylcarbamoyl oxime Drug Info [33]
219 Benzaldehyde O-4-methoxyphenylcarbamoyl oxime Drug Info [33]
220 Benzaldehyde O-4-propoxyphenylcarbamoyl oxime Drug Info [33]
221 Benzofuran-2-ylboronic acid Drug Info [34]
222 Benzo[b]thiophen-2-ylboronic acid Drug Info [34]
223 Benzylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
224 Biphenyl-3-ylboronic acid Drug Info [34]
225 Biphenyl-3-ylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
226 Biphenyl-3-ylcarbamic acid cyclohexyl ester Drug Info [25]
227 Biphenyl-4-ylboronic acid Drug Info [34]
228 BMS-1 Drug Info [45]
229 bromoenol lactone Drug Info [38]
230 Chlorphrifos oxon Drug Info [46]
231 Cyclobutylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
232 Cyclohexyl biphenyl-4-ylcarbamate Drug Info [40]
233 Cyclohexylcarbamic acidbiphenyl-3-yl ester Drug Info [37]
234 Cyclohexylmethylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
235 Cyclopentyl(5-(pyridin-2-yl)oxazol-2-yl)methanone Drug Info [36]
236 Cyclopentylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
237 Dodecane-1-sulfonyl fluoride Drug Info [42]
238 Ethyl octylfluorophosphonate Drug Info [46]
239 Fatty acid amide hydrolase inhibitors Drug Info [16]
240 Furan-2-ylmethylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
241 HTS-00798 Drug Info [41]
242 Indan-2-ylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
243 Isopropyl 4-nitrophenyl dodecylphosphonate Drug Info [42]
244 Isopropyl dodecylfluorophosphonate Drug Info [46]
245 Isopropylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
246 JNJ-1661010 Drug Info [47]
247 LY-2183240 Drug Info [38]
248 LY-2318912 Drug Info [48]
249 Methoxy arachidonyl fluorophosphonate Drug Info [49]
250 Methyl 2-(7-phenylheptanoyl)oxazole-4-carboxylate Drug Info [27]
251 Methyl 2-(7-phenylheptanoyl)oxazole-5-carboxylate Drug Info [26]
252 Methyl icosylphosphonofluoridate Drug Info [42]
253 Methylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
254 N-(2-hydroxyethyl)linoleoylamide Drug Info [50]
255 N-(2-iodethyl)arachidonylamide Drug Info [50]
256 N-(2-iodoethyl)linoleoylamide Drug Info [50]
257 N-(4-hydroxybenzyl)icosa-5,8,11,14-tetraenamide Drug Info [44]
258 N-arachidonylmaleimide Drug Info [25]
259 N-Butylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
260 N-Hexylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
261 N-Octylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
262 Naphthalen-2-yl cyclohexylcarbamate Drug Info [38]
263 NICARBAZIN Drug Info [51]
264 Nicotinaldehyde O-4-butoxyphenylcarbamoyl oxime Drug Info [33]
265 Nicotinaldehyde O-4-ethoxyphenylcarbamoyl oxime Drug Info [33]
266 Nicotinaldehyde O-4-propoxyphenylcarbamoyl oxime Drug Info [33]
267 Octane-1-sulfonyl fluoride Drug Info [42]
268 OL-135 Drug Info [52]
269 OL-92 Drug Info [45]
270 Org-231295 Drug Info [16], [31]
271 PARAOXON Drug Info [46]
272 PF3845 Drug Info [53]
273 PF750 Drug Info [54]
274 Phenethylboronic acid Drug Info [34]
275 Phenethylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
276 PHENMEDIPHAM Drug Info [51]
277 Phenyl 1-(4-butoxyphenyl)propylcarbamate Drug Info [33]
278 Phenyl 4-(decyloxy)phenylcarbamate Drug Info [33]
279 Phenyl 4-(dodecyloxy)phenylcarbamate Drug Info [33]
280 Phenyl 4-(heptyloxy)phenylcarbamate Drug Info [33]
281 Phenyl 4-(hexyloxy)phenylcarbamate Drug Info [33]
282 Phenyl 4-(octyloxy)phenylcarbamate Drug Info [33]
283 Phenyl 4-(undecyloxy)phenylcarbamate Drug Info [33]
284 Phenyl Boronic acid Drug Info [34]
285 Phenyl-1,4-bismaleimide Drug Info [25]
286 Phenylcarbamic Acid Biphenyl-3-yl Ester Drug Info [37]
287 Propan-2-one O-3-butoxyphenylcarbamoyl oxime Drug Info [33]
288 Propan-2-one O-4-(decyloxy)phenylcarbamoyl oxime Drug Info [33]
289 Propan-2-one O-4-(heptyloxy)phenylcarbamoyl oxime Drug Info [33]
290 Propan-2-one O-4-(hexyloxy)phenylcarbamoyl oxime Drug Info [33]
291 Propan-2-one O-4-(nonyloxy)phenylcarbamoyl oxime Drug Info [33]
292 Propan-2-one O-4-(octyloxy)phenylcarbamoyl oxime Drug Info [33]
293 Propan-2-one O-4-(pentyloxy)phenylcarbamoyl oxime Drug Info [33]
294 Propan-2-one O-4-butoxybenzylcarbamoyl oxime Drug Info [33]
295 Propan-2-one O-4-butoxyphenylcarbamoyl oxime Drug Info [33]
296 Propan-2-one O-4-ethoxyphenylcarbamoyl oxime Drug Info [33]
297 Propan-2-one O-4-propoxyphenylcarbamoyl oxime Drug Info [33]
298 Pyridin-3-yl 4-butoxybenzylcarbamate Drug Info [33]
299 VER-156084 Drug Info [55]
Modulator [+] 1 Modulator drugs +
1 IW-6118 Drug Info [12]
Target Profiles in Patients
Target Expression
 Profile (TEP)
Target Affiliated Biological Pathways
BioCyc [+] 1 BioCyc Pathways +
1 Anandamide degradation
KEGG Pathway [+] 1 KEGG Pathways +
1 Retrograde endocannabinoid signaling
Panther Pathway [+] 1 Panther Pathways +
1 Anandamide degradation
Target-Related Models and Studies
Target Validation
References
REF 1 The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. Br J Pharmacol. 2003 Jul;139(5):1005-13.
REF 2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5464).
REF 3 Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery. Curr Med Chem. 2000 Feb;7(2):249-71.
REF 4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2579).
REF 5 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 011679.
REF 6 ClinicalTrials.gov (NCT01107236) Study to Evaluate Efficacy and Safety of IW-6118 in Patients Undergoing Third Molar Extraction. U.S. National Institutes of Health.
REF 7 ClinicalTrials.gov (NCT02498392) An Efficacy, Safety and Tolerability Study of JNJ-42165279 in Participants With Major Depressive Disorder With Anxious Distress.
REF 8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6694).
REF 9 ClinicalTrials.gov (NCT00822744) An Eight-week Study of SSR411298 as Treatment for Major Depressive Disorder in Elderly Patients. U.S. National Institutes of Health.
REF 10 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029245)
REF 11 Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
REF 12 The Discovery and Development of Inhibitors of Fatty Acid Amide Hydrolase (FAAH). Bioorg Med Chem Lett. 2011 August 15; 21(16): 4674-4685.
REF 13 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
REF 14 Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor. ACS Med Chem Lett. 2011 Feb 10;2(2):91-96.
REF 15 Pharma & Vaccines. Product Development Pipeline. April 29 2009.
REF 16 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1400).
REF 17 Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66.
REF 18 A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351.
REF 19 3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4163-7.
REF 20 Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase. J Med Chem. 2007 Oct 4;50(20):5012-23.
REF 21 Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as a... J Med Chem. 2005 Mar 24;48(6):1849-56.
REF 22 Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95.
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