Target General Infomation
Target ID
T77009 (Former ID: TTDI00956)
Target Name
Thioredoxin reductase (PRDX5)
Thioredoxin peroxidase PMP20; TPx type VI; SBBI10; PrxV; Prx-V; Peroxisomal antioxidant enzyme; Peroxiredoxin5, mitochondrial; Peroxiredoxin-5, mitochondrial; Peroxiredoxin V; PLP; Liver tissue 2Dpage spot 71B; Liver tissue 2D-page spot 71B; Antioxidant enzyme B166; Alu corepressor 1; AOEB166; ACR1
Gene Name
Target Type
Successful target
Disease [+] 1 Target-related Diseases +
1 Brain cancer [ICD-11: 2A00]
Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.
BioChemical Class
Peroxide acceptor oxidoreductase
UniProt ID
EC Number
Drugs and Modes of Action
Approved Drug(s) [+] 1 Approved Drugs +
1 Motexafin gadolinium Drug Info Approved Brain cancer [2]
Mode of Action [+] 1 Modes of Action +
Modulator [+] 1 Modulator drugs +
1 Motexafin gadolinium Drug Info [1]
Target Regulators
Target-interacting Proteins
REF 1 Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd). Biochem Biophys Res Commun. 2009 Feb 13;379(3):775-9.
REF 2 Photodynamic therapy: applications in atherosclerotic vascular disease with motexafin lutetium. Catheter Cardiovasc Interv. 2002 Nov;57(3):387-94.
REF 3 Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556.

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