Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T15441
|
||||
| Target Name |
Ubiquitin C-terminal hydrolase UCH37 (UCHL5)
|
||||
| Synonyms |
Ubiquitin thioesterase L5; Ubiquitin carboxyl-terminal hydrolase isozyme L5; UCH37; UCH-L5; CGI-70; AD-019
|
||||
| Gene Name |
UCHL5
|
||||
| Target Type |
Patented-recorded target
|
[1] | |||
| Function |
Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains.
|
||||
| BioChemical Class |
Peptidase
|
||||
| UniProt ID | |||||
| EC Number |
EC 3.4.19.12
|
||||
| Sequence |
MTGNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQP
GEEPAGSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQS FDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAKEEDAFHFVSYVPVNGRLYELDG LREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQR QLAEEEPMDTDQGNSMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELL KTLAEHQQLIPLVEKAKEKQNAKKAQETK |
||||
| Mode of Action | [+] 1 Modes of Action | + | |||
| Inhibitor | [+] 1 Inhibitor drugs | + | |||
| 1 | PMID26077642-Compound-Figure3A | Drug Info | [1] | ||
| Target Regulators | |||||
| Target-interacting Proteins | |||||
| References | |||||
| REF 1 | Deubiquitinases (DUBs) and DUB inhibitors: a patent review.Expert Opin Ther Pat. 2015;25(10):1191-1208. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Wang and Dr. Li.