Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T68544
(Former ID: TTDI01802)
|
|||||
| Target Name |
Estrogen-related receptor (ESRR)
|
|||||
| Gene Name |
NO-GeName
|
|||||
| Target Type |
Literature-reported target
|
[1] | ||||
| Function |
Binds to an ERR-alpha response element (ERRE) containinga single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces theexpression of PERM1 in the skeletal muscle.
Click to Show/Hide
|
|||||
| UniProt ID | ||||||
| Target Poor or Non Binders | Top | |||||
|---|---|---|---|---|---|---|
| Target Poor or Non Binders | ||||||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Estrogen-related Receptor Reduces the Subnuclear Mobility of Estrogen Receptor and Suppresses Estrogen-dependent Cellular Function. J Biol Chem. 2015 May 8;290(19):12332-45. | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.