Resistance mutation info of target
| Target General Information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Target ID | T17345 | |||||||||||||||||
| Target Name | Bacterial Dihydrofolate reductase (DHFR) | |||||||||||||||||
| Gene Name | DHFR | |||||||||||||||||
| Species | Streptococcus pneumoniae | |||||||||||||||||
| UniProt ID | DYR_STRPN | |||||||||||||||||
| Sequence |
MTKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPK RETLILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTH IHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV [Streptococ cus pneumoniae] |
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| Drug and Corresponding Resistance Mutations | ||||||||||||||||||
| Mutation Info | Missense: V100L | |||||||||||||||||
| Drugs |
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| References | ||||||||||||||||||
| REF 1 | Kinetic and structural characterization of dihydrofolate reductase from Streptococcus pneumoniae. Biochemistry. 2010 Jan 12;49(1):195-206. | |||||||||||||||||
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