Resistance mutation info of target
| Target General Information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Target ID | T23036 | |||||||||||||||||
| Target Name | Bacterial Staphylococcus aureus Enoyl ACP reductase (fabI) | |||||||||||||||||
| Gene Name | fabI | |||||||||||||||||
| Species | Staphylococcus aureus | |||||||||||||||||
| UniProt ID | FABI_STAA8 | |||||||||||||||||
| Sequence |
MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEA HLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDI SSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGP DNIRVNAISASPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSG VTGENIHVDSGFHAIK [Staphylococcus aureus] |
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| Drug and Corresponding Resistance Mutations | ||||||||||||||||||
| Mutation Info | Missense: M99T | |||||||||||||||||
| Drugs |
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| Mutation Info | Missense: Y147H | |||||||||||||||||
| Drugs |
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| References | ||||||||||||||||||
| REF 1 | Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI). J Biol Chem. 2013 Dec 20;288(51):36261-71. | |||||||||||||||||
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