Resistance mutation info of target
| Target General Information | ||||||||||||||||||
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| Target ID | T27445 | |||||||||||||||||
| Target Name | Bacterial Isoleucyl-tRNA synthetase (ileS) | |||||||||||||||||
| Gene Name | ileS | |||||||||||||||||
| Species | Escherichia coli | |||||||||||||||||
| UniProt ID | SYI_ECOLI | |||||||||||||||||
| Sequence |
MSDYKSTLNLPETGFPMRGDLAKREPGMLARWTDDDLYGIIRAAKKGKKTFILHDGPPYA NGSIHIGHSVNKILKDIIVKSKGLSGYDSPYVPGWDCHGLPIELKVEQEYGKPGEKFTAA EFRAKCREYAATQVDGQRKDFIRLGVLGDWSHPYLTMDFKTEANIIRALGKIIGNGHLHK GAKPVHWCVDCRSALAEAEVEYYDKTSPSIDVAFQAVDQDALKAKFAVSNVNGPISLVIW TTTPWTLPANRAISIAPDFDYALVQIDGQAVILAKDLVESVMQRIGVTDYTILGTVKGAE LELLRFTHPFMGFDVPAILGDHVTLDAGTGAVHTAPGHGPDDYVIGQKYGLETANPVGPD GTYLPGTYPTLDGVNVFKANDIVVALLQEKGALLHVEKMQHSYPCCWRHKTPIIFRATPQ WFVSMDQKGLRAQSLKEIKGVQWIPDWGQARIESMVANRPDWCISRQRTWGVPMSLFVHK DTEELHPRTLELMEEVAKRVEVDGIQAWWDLDAKEILGDEADQYVKVPDTLDVWFDSGST HSSVVDVRPEFAGHAADMYLEGSDQHRGWFMSSLMISTAMKGKAPYRQVLTHGFTVDGQG RKMSKSIGNTVSPQDVMNKLGADILRLWVASTDYTGEMAVSDEILKRAADSYRRIRNTAR FLLANLNGFDPAKDMVKPEEMVVLDRWAVGCAKAAQEDILKAYEAYDFHEVVQRLMRFCS VEMGSFYLDIIKDRQYTAKADSVARRSCQTALYHIAEALVRWMAPILSFTADEVWGYLPG EREKYVFTGEWYEGLFGLADSEAMNDAFWDELLKVRGEVNKVIEQARADKKVGGSLEAAV TLYAEPELSAKLTALGDELRFVLLTSGATVADYNDAPADAQQSEVLKGLKVALSKAEGEK CPRCWHYTQDVGKVAEHAEICGRCVSNVAGDGEKRKFA [Escherichia coli] |
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| Drug and Corresponding Resistance Mutations | ||||||||||||||||||
| Mutation Info | Missense: F227L | |||||||||||||||||
| Drugs |
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| Mutation Info | Missense: FP187F | |||||||||||||||||
| Drugs |
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| Mutation Info | Missense: K226T | |||||||||||||||||
| Drugs |
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| Mutation Info | Missense: Q612H | |||||||||||||||||
| Drugs |
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| Mutation Info | Missense: V588 | |||||||||||||||||
| Drugs |
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| Mutation Info | Missense: V767D | |||||||||||||||||
| Drugs |
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| References | ||||||||||||||||||
| REF 1 | Molecular analysis of isoleucyl-tRNA synthetase mutations in clinical isolates of methicillin-resistant Staphylococcus aureus with low-level mupiro... J Korean Med Sci. 2006 Oct;21(5):827-32. | |||||||||||||||||
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