Resistance mutation info of target
| Target General Information | ||||||||||||||||||
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| Target ID | T40016 | |||||||||||||||||
| Target Name | Glucocorticoid receptor (NR3C1) | |||||||||||||||||
| Gene Name | NR3C1 | |||||||||||||||||
| Species | Homo sapiens | |||||||||||||||||
| UniProt ID | GCR_HUMAN | |||||||||||||||||
| Sequence |
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK [H omo sapiens] |
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| Drug and Corresponding Resistance Mutations | ||||||||||||||||||
| Mutation Info | Missense: L672P | |||||||||||||||||
| Drugs |
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| Mutation Info | Missense: R477S | |||||||||||||||||
| Drugs |
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| Mutation Info | Missense: Y478C | |||||||||||||||||
| Drugs |
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| References | ||||||||||||||||||
| REF 1 | Three Novel Heterozygous Point Mutations of NR3C1 Causing Glucocorticoid Resistance.Hum Mutat.2016 Aug;37(8):794-803. | |||||||||||||||||
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