Target General Information
Target ID T79068
Target Name Bacterial Enoyl-[acyl-carrier-protein] reductase [NADH] (Inha)
Gene Name inhA
Species Mycobacterium tuberculosis
UniProt ID INHA_MYCTU
Sequence MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPL
LELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGI
HISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAG
KYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAK
TVCALLSDWLPATTGDIIYADGGAHTQLL [Mycobacterium tuberculosis]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: E217D
Drugs
Drug Name Isoniazid Drug Info [9]
Targeted Disease Tuberculosis
Mutation Prevalence 1 out of 28 isolates
Mutation Info Missense: I16T
Drugs
Drug Name Isoniazid Drug Info [2], [4]
Targeted Disease Tuberculosis
Mutation Info Missense: I194T
Drugs
Drug Name Isoniazid Drug Info [2], [5]
Targeted Disease Tuberculosis
Mutation Prevalence 52 out of 102 isolates
Mutation Info Missense: I21T
Drugs
Drug Name Isoniazid Drug Info [2], [3]
Targeted Disease Tuberculosis
Mutation Info Missense: I21V
Drugs
Drug Name Isoniazid Drug Info [2], [3]
Targeted Disease Tuberculosis
Mutation Info Missense: I47T
Drugs
Drug Name Isoniazid Drug Info [2], [4]
Targeted Disease Tuberculosis
Mutation Info Missense: I95P
Drugs
Drug Name Isoniazid Drug Info [2], [6]
Targeted Disease Tuberculosis
Mutation Prevalence 7 out of 14 isolates
Drug Name Ethionamide Drug Info [6]
Targeted Disease Tuberculosis
Mutation Prevalence 7 out of 14 isolates
Mutation Info Missense: I95T
Drugs
Drug Name Isoniazid Drug Info [7]
Targeted Disease Tuberculosis
Mutation Info Missense: K8N
Drugs
Drug Name Isoniazid Drug Info []
Targeted Disease Tuberculosis
Mutation Info Missense: R202G
Drugs
Drug Name Isoniazid Drug Info [9]
Targeted Disease Tuberculosis
Mutation Prevalence 1 out of 28 isolates
Mutation Info Missense: S94A
Drugs
Drug Name Isoniazid Drug Info [1], [2]
Targeted Disease Tuberculosis
Drug Name Ethionamide Drug Info [1]
Targeted Disease Tuberculosis
Mutation Info Missense: S94L
Drugs
Drug Name Isoniazid Drug Info [8]
Targeted Disease Tuberculosis
Mutation Info Missense: V78A
Drugs
Drug Name Isoniazid Drug Info [2], [4]
Targeted Disease Tuberculosis
References
REF 1 Exclusive mutations related to isoniazid and ethionamide resistance among Mycobacterium tuberculosis isolates from Korea. Int J Tuberc Lung Dis. 2000 May;4(5):441-7.
REF 2 CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573.
REF 3 ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates. Antimicrob Agents Chemother. 2003 Dec;47(12):3799-805.
REF 4 Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates. J Infect Dis. 1998 Sep;178(3):769-75.
REF 5 Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis: identification of a novel mutation in inhA. Antimicrob Agents Chemother. 2006 Mar;50(3):1075-8.
REF 6 New isoniazid/ethionamide resistance gene mutation and screening for multidrug-resistant Mycobacterium tuberculosis strains. Lancet. 1995 Aug 19;346(8973):502-3.
REF 7 Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update. Tuber Lung Dis. 1998;79(1):3-29.
REF 8 Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Nat Med. 2006 Sep;12(9):1027-9.
REF 9 Performance assessment of the GenoType MTBDRplus test and DNA sequencing in detection of multidrug-resistant Mycobacterium tuberculosis. J Clin Microbiol. 2009 Aug;47(8):2520-4.

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