Resistance mutation info of target

Target General Information
Target ID T81503
Target Name Bacterial DNA gyrase subunit B (gyrB)
Gene Name gyrB
Species Mycobacterium tuberculosis
UniProt ID GYRB_MYCTU
Sequence MAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
YATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGL
HGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVF
ETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAES
TAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISV
KVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKK
INKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARR
SFITRNAKDVRFLDV [Mycobacterium tuberculosis]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: A473V
Drugs
Drug Name Fluoroquinolones Drug Info [5]
Mutation Info Missense: A515T
Drugs
Drug Name Fluoroquinolones Drug Info [7]
Mutation Prevalence 1 out of 48 isolates
Mutation Info Missense: A515V
Drugs
Drug Name Fluoroquinolones Drug Info [7]
Mutation Prevalence 3 out of 48 isolates
Mutation Info Missense: D464N
Drugs
Drug Name Fluoroquinolone Drug Info [1]
Mutation Info Missense: D472A
Drugs
Drug Name Fluoroquinolones Drug Info [3]
Mutation Info Missense: D472H
Drugs
Drug Name Fluoroquinolones Drug Info [2], [3]
Mutation Info Missense: D472N
Drugs
Drug Name Fluoroquinolones Drug Info [3], [4]
Mutation Info Missense: D476N
Drugs
Drug Name Fluoroquinolones Drug Info [1]
Mutation Info Missense: D505A
Drugs
Drug Name Fluoroquinolones Drug Info [6]
Mutation Info Missense: E466D
Drugs
Drug Name Fluoroquinolone Drug Info [5]
Mutation Info Missense: E502Q
Drugs
Drug Name Fluoroquinolone Drug Info [5]
Mutation Info Missense: E504V
Drugs
Drug Name Fluoroquinolone Drug Info [1]
Mutation Info Missense: E512D
Drugs
Drug Name Fluoroquinolones Drug Info [3]
Mutation Info Missense: E512V
Drugs
Drug Name Fluoroquinolones Drug Info [3]
Mutation Info Missense: G124S
Drugs
Drug Name Aminocoumarin Drug Info [1]
Mutation Info Missense: G481A
Drugs
Drug Name Fluoroquinolones Drug Info [3]
Mutation Info Missense: G78S
Drugs
Drug Name Aminocoumarin Drug Info [5]
Mutation Info Missense: G85S
Drugs
Drug Name Aminocoumarin Drug Info [5]
Mutation Info Missense: I102S
Drugs
Drug Name Aminocoumarin Drug Info [5]
Mutation Info Missense: I56S
Drugs
Drug Name Aminocoumarin Drug Info [5]
Mutation Info Missense: M437I
Drugs
Drug Name Fluoroquinolones Drug Info [5]
Mutation Info Missense: N502D
Drugs
Drug Name Fluoroquinolone Drug Info [1]
Mutation Info Missense: N510D
Drugs
Drug Name Fluoroquinolones Drug Info [2]
Mutation Info Missense: N510T
Drugs
Drug Name Fluoroquinolones Drug Info [3]
Mutation Info Missense: N52T
Drugs
Drug Name Streptomycin Drug Info [1]
Targeted Disease Tuberculosis
Mutation Info Missense: P462S
Drugs
Drug Name Fluoroquinolone Drug Info [5]
Mutation Info Missense: Q510K
Drugs
Drug Name Fluoroquinolones Drug Info [7]
Mutation Prevalence 1 out of 48 isolates
Mutation Info Missense: Q549H
Drugs
Drug Name Fluoroquinolones Drug Info [7]
Mutation Prevalence 1 out of 48 isolates
Mutation Info Missense: R136C
Drugs
Drug Name Aminocoumarin Drug Info [1]
Mutation Info Missense: R136E
Drugs
Drug Name Aminocoumarin Drug Info [1]
Mutation Info Missense: R136G
Drugs
Drug Name Aminocoumarin Drug Info [1], [5]
Drug Name Aminocoumarin Drug Info [1], [5]
Mutation Info Missense: R136H
Drugs
Drug Name Aminocoumarin Drug Info [1]
Mutation Info Missense: R136I
Drugs
Drug Name Aminocoumarin Drug Info [1]
Mutation Info Missense: R136L
Drugs
Drug Name Aminocoumarin Drug Info [1]
Mutation Info Missense: R136S
Drugs
Drug Name Aminocoumarin Drug Info [1]
Mutation Info Missense: R144I
Drugs
Drug Name Aminocoumarin Drug Info [5]
Mutation Info Missense: R144S
Drugs
Drug Name Aminocoumarin Drug Info [5]
Mutation Info Missense: R184Q
Drugs
Drug Name Aminocoumarin Drug Info [1]
Mutation Info Missense: R457C
Drugs
Drug Name Fluoroquinolones Drug Info [8]
Mutation Info Missense: S128L
Drugs
Drug Name Aminocoumarin Drug Info [5]
Mutation Info Missense: S458F
Drugs
Drug Name Fluoroquinolones Drug Info [3]
Mutation Info Missense: S464Y
Drugs
Drug Name Fluoroquinolone Drug Info [1]
Mutation Info Missense: T173A
Drugs
Drug Name Aminocoumarin Drug Info [5]
Mutation Info Missense: T214A
Drugs
Drug Name Aminocoumarin Drug Info [1]
Mutation Info Missense: T214I
Drugs
Drug Name Aminocoumarin Drug Info [1]
Mutation Info Missense: T511P
Drugs
Drug Name Fluoroquinolones Drug Info [3]
Mutation Info Missense: V461G
Drugs
Drug Name Fluoroquinolones Drug Info [5]
References
REF 1 CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573.
REF 2 Novel gyrase mutations in quinolone-resistant and -hypersusceptible clinical isolates of Mycobacterium tuberculosis: functional analysis of mutant enzymes. Antimicrob Agents Chemother. 2006 Jan;50(1):104-12.
REF 3 Beijing genotype of Mycobacterium tuberculosis is significantly associated with high-level fluoroquinolone resistance in Vietnam. Antimicrob Agents Chemother. 2009 Nov;53(11):4835-9.
REF 4 Mutations in the gyrA and gyrB genes of fluoroquinolone-resistant Mycobacterium tuberculosis from TB patients in Thailand. Southeast Asian J Trop Med Public Health. 2005;36 Suppl 4:228-37.
REF 5 The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57.
REF 6 Characterization of pyrazinamide and ofloxacin resistance among drug resistant Mycobacterium tuberculosis isolates from Singapore. Int J Infect Dis. 2002 Mar;6(1):48-51.
REF 7 Molecular characterization of ofloxacin-resistant Mycobacterium tuberculosis strains from Russia. Antimicrob Agents Chemother. 2008 Aug;52(8):2937-9.
REF 8 Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. Antimicrob Agents Chemother. 2009 Aug;53(8):3248-55.

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