Resistance mutation info of target
| Target General Information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Target ID | T98089 | |||||||||||||||||
| Target Name | Deoxycytidine kinase (DCK) | |||||||||||||||||
| Gene Name | DCK | |||||||||||||||||
| Species | Homo sapiens | |||||||||||||||||
| UniProt ID | DCK_HUMAN | |||||||||||||||||
| Sequence |
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE DFKDKYESLVEKVKEFLSTL [Homo sapiens] |
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| Drug and Corresponding Resistance Mutations | ||||||||||||||||||
| Mutation Info | Missense: E197K | |||||||||||||||||
| Drugs |
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| References | ||||||||||||||||||
| REF 1 | Acquisition of chemoresistance to gemcitabine is induced by a loss-of-function missense mutation of DCK.Biochem Biophys Res Commun.2015 Sep 4;464(4):1084-9. | |||||||||||||||||
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