Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX0MDB
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| Drug Name |
(S)-3-Methyl-2-[3-(2-trifluoromethyl-phenyl)-ureido]-pentanoic acid [(R)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide
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| Synonyms |
CHEMBL1790991
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C25H27F3N4O3
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| Canonical SMILES |
CC[C@@H](C)[C@H](NC(=O)Nc1ccccc1C(F)(F)F)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C=O
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| InChI |
InChI=1S/C25H27F3N4O3/c1-3-15(2)22(32-24(35)31-21-11-7-5-9-19(21)25(26,27)28)23(34)30-17(14-33)12-16-13-29-20-10-6-4-8-18(16)20/h4-11,13-15,17,22,29H,3,12H2,1-2H3,(H,30,34)(H2,31,32,35)/t15-,17-,22+/m1/s1
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| InChIKey |
YYIPDPNKLCJYIH-JLDZCNIISA-N
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| Target and Pathway | |||||
| Target(s) | Cathepsin L | Target Info | [1587926] | ||
| Cathepsin B | Target Info | [1587926] | |||
| Reactome | Endosomal/Vacuolar pathway | ||||
| Collagen degradation | |||||
| Degradation of the extracellular matrix | |||||
| Trafficking and processing of endosomal TLR | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| MHC class II antigen presentationR-HSA-1442490:Collagen degradation | |||||
| MHC class II antigen presentation | |||||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | ||||
| References | |||||
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