Drug General Information
Drug ID
DX0MVX
Drug Name
((R)-1-Benzyloxycarbonylamino-2-phenyl-ethyl)-[2-((S)-1-carbamoyl-2-methyl-propylcarbamoyl)-3-phenyl-propyl]-phosphinic acid
Synonyms
CHEMBL424591
Indication Discovery agent Investigative [1587926]
Formula
C31H38N3O6P
Canonical SMILES
CC(C)[C@H](NC(=O)C(Cc1ccccc1)CP(=O)(O)[C@H](Cc2ccccc2)NC(=O)OCc3ccccc3)C(=O)N
InChI
InChI=1S/C31H38N3O6P/c1-22(2)28(29(32)35)34-30(36)26(18-23-12-6-3-7-13-23)21-41(38,39)27(19-24-14-8-4-9-15-24)33-31(37)40-20-25-16-10-5-11-17-25/h3-17,22,26-28H,18-21H2,1-2H3,(H2,32,35)(H,33,37)(H,34,36)(H,38,39)/t26?,27-,28+/m1/s1
InChIKey
OTZGSMXWHJLTCA-OEBVTXOESA-N
Target and Pathway
Target(s) Neutrophil collagenase Target Info [1587926]
Matrix metalloproteinase-14 Target Info [1587926]
KEGG Pathway TNF signaling pathway
GnRH signaling pathway
PANTHER Pathway Alzheimer disease-presenilin pathwayP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database HIF-2-alpha transcription factor network
Signaling events mediated by focal adhesion kinase
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix MetalloproteinasesR-HSA-1442490:Collagen degradation
Activation of Matrix Metalloproteinases
WikiPathways Activation of Matrix Metalloproteinases
Matrix MetalloproteinasesWP615:Senescence and Autophagy in Cancer
Degradation of collagen
AGE/RAGE pathway
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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