Drug General Information
Drug ID
DX0NHI
Drug Name
N-{8-Chloro-11-[1-(2-pyridin-4-yl-acetyl)-piperidin-4-ylidene]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-yl}-methanesulfonamide
Synonyms
CHEMBL135374
Indication Discovery agent Investigative [1587926]
Formula
C27H27ClN4O3S
Canonical SMILES
CS(=O)(=O)Nc1cnc2C(=C3CCN(CC3)C(=O)Cc4ccncc4)c5ccc(Cl)cc5CCc2c1
InChI
InChI=1S/C27H27ClN4O3S/c1-36(34,35)31-23-16-21-3-2-20-15-22(28)4-5-24(20)26(27(21)30-17-23)19-8-12-32(13-9-19)25(33)14-18-6-10-29-11-7-18/h4-7,10-11,15-17,31H,2-3,8-9,12-14H2,1H3
InChIKey
UMEAOCQWTBLFJV-UHFFFAOYSA-N
Target and Pathway
Target(s) Farnesyltransferase Target Info [1587926]
Protein farnesyltransferase beta subunit Target Info [1587926]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibioticshsa00900:Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascadeR-HSA-2514859:Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransduction
Apoptotic execution phaseWP2776:Visual phototransduction
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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