Drug General Information
Drug ID
DX0OFD
Drug Name
(S)-N-(1-(2-(4-methoxy-2,6-dimethylphenylamino)ethylamino)-4-methyl-1-oxopentan-2-yl)-3-methylbenzamide
Synonyms
CHEMBL202958
Indication Discovery agent Investigative [1587926]
Formula
C25H35N3O3
Canonical SMILES
COc1cc(C)c(NCCNC(=O)[C@H](CC(C)C)NC(=O)c2cccc(C)c2)c(C)c1
InChI
InChI=1S/C25H35N3O3/c1-16(2)12-22(28-24(29)20-9-7-8-17(3)13-20)25(30)27-11-10-26-23-18(4)14-21(31-6)15-19(23)5/h7-9,13-16,22,26H,10-12H2,1-6H3,(H,27,30)(H,28,29)/t22-/m0/s1
InChIKey
RNVBYSSYXDLACM-QFIPXVFZSA-N
Target and Pathway
Target(s) Cathepsin K Target Info [1587926]
Cathepsin L Target Info [1587926]
KEGG Pathway Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritishsa04142:Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling PathwayNetPath_16:IL4 Signaling Pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways RANKL/RANK Signaling Pathway
Osteoclast SignalingWP2572:Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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