Drug General Information
Drug ID
DX0OTN
Drug Name
N-((S)-1-((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)-3-(1-methylcyclopentyl)-1-oxopropan-2-yl)furan-2-carboxamide
Synonyms
CHEMBL1807651
Indication Discovery agent Investigative [1587926]
Formula
C26H34N4O6S
Canonical SMILES
C[C@@H]1CC[C@H](NC(=O)[C@H](CC2(C)CCCC2)NC(=O)c3occc3)C(=O)CN1S(=O)(=O)c4ccccn4
InChI
InChI=1S/C26H34N4O6S/c1-18-10-11-19(21(31)17-30(18)37(34,35)23-9-3-6-14-27-23)28-24(32)20(16-26(2)12-4-5-13-26)29-25(33)22-8-7-15-36-22/h3,6-9,14-15,18-20H,4-5,10-13,16-17H2,1-2H3,(H,28,32)(H,29,33)/t18-,19+,20+/m1/s1
InChIKey
GIQMZBQRQSROHM-AABGKKOBSA-N
Target and Pathway
Target(s) Cathepsin K Target Info [1587926]
Cathepsin L Target Info [1587926]
KEGG Pathway Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritishsa04142:Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling PathwayNetPath_16:IL4 Signaling Pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways RANKL/RANK Signaling Pathway
Osteoclast SignalingWP2572:Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.