Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX0WRI
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| Drug Name |
(S)-N-((S)-1-cyano-2-phenylethyl)-3-phenyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)propanamide
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| Synonyms |
CHEMBL1288529
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C33H30F3N3O3S
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| Canonical SMILES |
CS(=O)(=O)c1ccc(cc1)c2ccc(cc2)[C@H](N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc4ccccc4)C#N)C(F)(F)F
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| InChI |
InChI=1S/C33H30F3N3O3S/c1-43(41,42)29-18-16-26(17-19-29)25-12-14-27(15-13-25)31(33(34,35)36)39-30(21-24-10-6-3-7-11-24)32(40)38-28(22-37)20-23-8-4-2-5-9-23/h2-19,28,30-31,39H,20-21H2,1H3,(H,38,40)/t28-,30-,31-/m0/s1
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| InChIKey |
SDBNYBMBPYRBSJ-ASVWTAOFSA-N
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| Target and Pathway | |||||
| Target(s) | Cathepsin L | Target Info | [1587926] | ||
| Cathepsin B | Target Info | [1587926] | |||
| Reactome | Endosomal/Vacuolar pathway | ||||
| Collagen degradation | |||||
| Degradation of the extracellular matrix | |||||
| Trafficking and processing of endosomal TLR | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| MHC class II antigen presentationR-HSA-1442490:Collagen degradation | |||||
| MHC class II antigen presentation | |||||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | ||||
| References | |||||
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