Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX1AFN
|
||||
| Drug Name |
(R)-3-(2,3-difluorobenzylsulfonyl)-N-(1-cyanocyclopropyl)-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)propanamide
|
||||
| Synonyms |
CHEMBL400750
|
||||
| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C22H19F6N3O3S
|
||||
| Canonical SMILES |
Fc1ccc(cc1)[C@H](N[C@@H](CS(=O)(=O)Cc2cccc(F)c2F)C(=O)NC3(CC3)C#N)C(F)(F)F
|
||||
| InChI |
InChI=1S/C22H19F6N3O3S/c23-15-6-4-13(5-7-15)19(22(26,27)28)30-17(20(32)31-21(12-29)8-9-21)11-35(33,34)10-14-2-1-3-16(24)18(14)25/h1-7,17,19,30H,8-11H2,(H,31,32)/t17-,19-/m0/s1
|
||||
| InChIKey |
SQIHYRIDUCIHLT-HKUYNNGSSA-N
|
||||
| Target and Pathway | |||||
| Target(s) | Cathepsin L | Target Info | [1587926] | ||
| Cathepsin B | Target Info | [1587926] | |||
| Reactome | Endosomal/Vacuolar pathway | ||||
| Collagen degradation | |||||
| Degradation of the extracellular matrix | |||||
| Trafficking and processing of endosomal TLR | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| MHC class II antigen presentationR-HSA-1442490:Collagen degradation | |||||
| MHC class II antigen presentation | |||||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | ||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.