Drug General Information
Drug ID
DX1AU9
Drug Name
4'-Iodo-biphenyl-4-carboxylic acid {1-[(S)-1-(2-diazo-acetyl)-butylcarbamoyl]-3-methyl-butyl}-amide
Synonyms
CHEMBL518284
Indication Discovery agent Investigative [1587926]
Formula
C25H29IN4O3
Canonical SMILES
CCC[C@H](NC(=O)C(CC(C)C)NC(=O)c1ccc(cc1)c2ccc(I)cc2)C(=O)C=[N+]=[N-]
InChI
InChI=1S/C25H29IN4O3/c1-4-5-21(23(31)15-28-27)29-25(33)22(14-16(2)3)30-24(32)19-8-6-17(7-9-19)18-10-12-20(26)13-11-18/h6-13,15-16,21-22H,4-5,14H2,1-3H3,(H,29,33)(H,30,32)/t21-,22?/m0/s1
InChIKey
VHNVOAVIDBRLFO-HMTLIYDFSA-N
Target and Pathway
Target(s) Cathepsin L Target Info [1587926]
Cathepsin B Target Info [1587926]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritishsa04142:Lysosome
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentationR-HSA-1442490:Collagen degradation
MHC class II antigen presentation
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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