Drug Information

Drug General Information
Drug ID
DX1EPK
Drug Name
{2-[4-(4-Cyano-phenoxy)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinolin-3-yl}-oxo-acetic acid
Synonyms
CHEMBL140368
Indication Discovery agent Investigative [1587926]
Formula
C24H18N2O6S
Canonical SMILES
OC(=O)C(=O)C1Cc2ccccc2CN1S(=O)(=O)c3ccc(Oc4ccc(cc4)C#N)cc3
InChI
InChI=1S/C24H18N2O6S/c25-14-16-5-7-19(8-6-16)32-20-9-11-21(12-10-20)33(30,31)26-15-18-4-2-1-3-17(18)13-22(26)23(27)24(28)29/h1-12,22H,13,15H2,(H,28,29)
InChIKey
WVDBZKCLVKPIHE-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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