Drug General Information
Drug ID
DX1GNA
Drug Name
(S)-2-((S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2,2,2-trifluoroethylamino)-N-((S)-1-cyano-2-phenylethyl)-4-fluoro-4-methylpentanamide
Synonyms
CHEMBL1289764
Indication Discovery agent Investigative [1587926]
Formula
C26H27F4N5O
Canonical SMILES
CC(C)(F)C[C@H](N[C@@H](c1ccc(cc1)c2cn[nH]c2)C(F)(F)F)C(=O)N[C@@H](Cc3ccccc3)C#N
InChI
InChI=1S/C26H27F4N5O/c1-25(2,27)13-22(24(36)34-21(14-31)12-17-6-4-3-5-7-17)35-23(26(28,29)30)19-10-8-18(9-11-19)20-15-32-33-16-20/h3-11,15-16,21-23,35H,12-13H2,1-2H3,(H,32,33)(H,34,36)/t21-,22-,23-/m0/s1
InChIKey
CGAOFGCVDRGRSC-VABKMULXSA-N
Target and Pathway
Target(s) Cathepsin L Target Info [1587926]
Cathepsin B Target Info [1587926]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritishsa04142:Lysosome
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentationR-HSA-1442490:Collagen degradation
MHC class II antigen presentation
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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