Drug Information
Drug General Information | |||||
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Drug ID |
DX1HFS
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Drug Name |
N-(2-(2-(4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy)ethoxy)ethyl)-5-(2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
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Synonyms |
CHEMBL199725
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Indication | Discovery agent | Investigative | [1587926] | ||
Formula |
C29H34ClFN6O5S
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Canonical SMILES |
COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCOCCNC(=O)CCCCC4SCC5NC(=O)NC45
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InChI |
InChI=1S/C29H34ClFN6O5S/c1-40-23-13-18-21(33-16-34-28(18)35-20-7-6-17(30)12-19(20)31)14-24(23)42-11-10-41-9-8-32-26(38)5-3-2-4-25-27-22(15-43-25)36-29(39)37-27/h6-7,12-14,16,22,25,27H,2-5,8-11,15H2,1H3,(H,32,38)(H,33,34,35)(H2,36,37,39)
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InChIKey |
WIPRNDUMGQLIIL-UHFFFAOYSA-N
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Target and Pathway | |||||
Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
Vascular endothelial growth factor receptor 1 | Target Info | [1587926] | |||
KEGG Pathway | Ras signaling pathway | ||||
Rap1 signaling pathway | |||||
Cytokine-cytokine receptor interaction | |||||
Endocytosis | |||||
PI3K-Akt signaling pathway | |||||
VEGF signaling pathway | |||||
Focal adhesion | |||||
Proteoglycans in cancerhsa04014:Ras signaling pathway | |||||
HIF-1 signaling pathway | |||||
Transcriptional misregulation in cancer | |||||
Rheumatoid arthritis | |||||
NetPath Pathway | IL2 Signaling Pathway | ||||
PANTHER Pathway | Angiogenesis | ||||
VEGF signaling pathway | |||||
Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
Beta3 integrin cell surface interactions | |||||
Signaling events mediated by TCPTP | |||||
SHP2 signaling | |||||
S1P1 pathway | |||||
VEGF and VEGFR signaling network | |||||
Integrins in angiogenesis | |||||
Signaling events mediated by VEGFR1 and VEGFR2 | |||||
Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network | |||||
S1P3 pathway | |||||
VEGFR1 specific signals | |||||
References |
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