Drug Information

Drug General Information
Drug ID
DX2FBV
Drug Name
6-Methyl-3-(1H-pyrazol-4-yl)-N-[3-[(3,3,4,4-tetrafluoro-1-pyrrolidinyl)methyl]-5-isothiazolyl]imidazo[1,2-a]pyrazin-8-amine Hydrochloride
Synonyms
CHEMBL1650546
Indication Discovery agent Investigative [1587926]
Formula
C18H17ClF4N8S
Canonical SMILES
Cl.Cc1cn2c(cnc2c(Nc3cc(CN4CC(F)(F)C(F)(F)C4)ns3)n1)c5cn[nH]c5
InChI
InChI=1S/C18H16F4N8S.ClH/c1-10-6-30-13(11-3-24-25-4-11)5-23-16(30)15(26-10)27-14-2-12(28-31-14)7-29-8-17(19,20)18(21,22)9-29;/h2-6H,7-9H2,1H3,(H,24,25)(H,26,27);1H
InChIKey
ZPCNGKXIFOTRNL-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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