Drug General Information
Drug ID
DX2NZC
Drug Name
5-(4-(1-(hydroxyimino)-2,2-dimethylpropyl)phenyl)-1-methyl-1H-pyrrole-2-carbonitrile
Synonyms
CHEMBL1209298
Indication Discovery agent Investigative [1587926]
Formula
C17H19N3O
Canonical SMILES
Cn1c(ccc1c2ccc(cc2)\\C(=N/O)\\C(C)(C)C)C#N
InChI
InChI=1S/C17H19N3O/c1-17(2,3)16(19-21)13-7-5-12(6-8-13)15-10-9-14(11-18)20(15)4/h5-10,21H,1-4H3/b19-16+
InChIKey
BNYATMGZJPIGMW-KNTRCKAVSA-N
Target and Pathway
Target(s) Progesterone receptor Target Info [1587926]
mRNA of androgen receptor Target Info [1587926]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturationhsa04114:Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Cellular roles of Anthrax toxinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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